Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Lymphoid leukemias
| Question | Answer |
|---|---|
| Relative or absolute increase in lymphocytes | Lymphocytosis |
| Increase in the percentage of lymphs. Usually second to Neutropenia. Seen in some viral infections | Relative lymphocytosis. |
| increase > 4.4x10^9/L. Often not accompanied by a leukocytosis except IM, CMV, and infectious lymphocytosis | Absolute lymphocytosis |
| relative or absolute decrease in lymphocytes | lymphocytopenia |
| decrease in the percentage of lymphs. seen in CHF, uremia and malaria | relative lymphocytopenia |
| lymph decrease <1.0x10^9/L. seen in patients with breast/stomach cancers, active tuberculosis, malnutrition, after radiation or chemo and stress | absolute lymphocytopenia |
| lighter, lacier chromatin, too much cytoplasm to be a blast | reactive lymph |
| only lymph that can be reactive | B cell |
| a variant of a reactive lymph whose development in between lymph and plasma cell | plasmacytoid lymphocyte |
| type of leukocytosis in IM and CMV | absolute |
| lymphs in IM | 50-90% reactive |
| serological testing for IM | heterophile antibody |
| VCA-IgM; VCA-IgG; and EBNA | antibody titers for IM |
| increased serum bilirubin, increased AST, decreased alkaline phosphatase are abnormal liver function tests in | IM and CMV |
| unexpected antibody that can cause IM | Anti-i |
| lymphs in CMV | 90% reactive |
| Anti-CMV or culture of CMV from urine or serum | serological test |
| age - 15-25 etiologic agent - EBV lymph morphology - many reactive lymphs symptoms - severe, liver disease, even death | Infectious Mono |
| age - children etiologic agent - coxsackie or adenovirus lymph morphology - small, mature lymphs symptoms - mild, usually only diarrhea | Infectious lymphocytosis |
| viral mumps, measles, rubella, varicella, hepatitis, and flu coccidian toxoplasmosis are causes of | relative and reactive lymphocytosis |
| bacteria, bordetella pertussis, cat scratch disease (bartonella), mycobacteria (AFB), mycoplasma pneumoniae are causes of | relative, non-reactive lymphocytosis |
| a group of malignant leukocytoses resulting from cells rapidly multiplying in the lymphoid tissue and infiltrating the lymph nodes. includes CLL, HCL, MM, and Waldenstrom's macroglobulinemia | lymphoproliferative disorders |
| seen in men >40 average survival without treatment - 6 years autoimmune, hemolytic anemia DAT + | CLL |
| mix 5 drops blood with 1 drop 22% BSA to reduce the # of | smudge cells |
| rare, chronic B cell leukemia affecting middle aged men survival time - 17 years caused by HTLV-1 and radiation pancytopenia produces a dry tap | Hairy Cell Leukemia |
| large lymphs with gray cytoplasm that have hair-like or irregular extensions. nucleus is notched, dumbbell or oval | hairy cell |
| stains hairy cells | TRAP |
| a lymphoproliferative condition of plasma cells in the bone marrow seen mostly in middle aged men 50-60 years. xray of bones shows a punched out appearance | Multiple myeloma |
| light chains in urine | Bence Jones |
| protein electrophoresis in MM in IgG area | M spike |
| made up of IgG | russell bodies |
| a malignant proliferation of plasma cells seen in older patients 60-70 years. mean survival time of 4 years. increased ESR, and bleeding time. monoclonal IgM spike, lymphocytoid are predominant cells | waldenstrom's macroglobulinemia |
| a disease of the lymph nodes where mature or immature lymphs or reticulum cells infiltrate not only the lymphoid tissue and lymph nodes but other organs as well. | malignant lymphoma |
| location of leukemias | bone marrow |
| bimodal - 15-35 year old and > 50 year olds normo, normo anemia, Reed-Sternberg cells with lymphs, histocytes and eos | Hodgkin's lymphoma |
| very large reticulum cell AKA Owl's Eye 2 nuclei or multi-lobed nucleus Dense nucleolus surrounded by a clear zone diagnostic for Hodgkins | Reed-Sternberg |
| most common neoplasm in 20-40 year olds can be induced by exposure to chemicals, pesticides or organic solvents | non-hodgkin's |
| a rare cutaneous mature T cell lymphoma that spreads to organs occurs in middle aged people mean survival time 2 years | Mycodisis fungoides |
| the leukemic phase of mycoidisis fungoides | sezary syndrome |
| large form with a vacuolated cytoplasm and a convoluted nucleus | sezary cell |
| b-glucocerebrosidase deficiency that results in accumulation of glucocerebrosides in RES and CNS | Gaucher's Disorder |
| large cell with small eccentric nucleus, wrinkled or striated cytoplasm. "chicken scratch/gauges" | Gaucher cell |
| inherited disorder with variable geographic distribution, Ashkenazis Jew, Americans, Nova Scotians. Caused by deficiency of sphingomyelinase so sphingomyelin accumulates in RES tissues and brain. often fatal within 3 years in children | Neimann-Pick disorder |
| large cell, small eccentric nucleus, cytoplasm appears foamy or globular | Neimann-Pick cell |
| benign familial condition with unclear etiology accumulation of cerebrosides and carbohydrates in histiocytes in liver, spleen and bone marrow | sea blue histiocyte condition |
| large cell, eccentric nucleus, abundant cytoplasm filled with blue to blue green granules | sea blue histiocyte |
| most common in children aged 2-10 with peaks in 2-5 year olds and a second in the elderly. | ALL |
| most common ALL immunophenotype in children | Precursor B |
| more common ALL immunophenotype in adults | T Cell |
| more common ALL immunophenotype occurs in teenage males with mediastinal mass | immature T |
| rarest form of ALL immunophenotype occurs in children and adults | mature B |
| chromosomal abnormalities with poor prognosis | t(1;19), t(8;14), t(9;22) |
| chromosomal abnormalities with excellent prognosis | t(12;21) |
| best prognosis occurs in pre b with | CALLa |
| CALLa CD marker | CD10 |
| more common in children; best prognosis, may be any B or T subgroup | L1 lymphoblast |
| more common in adults; intermediate to poor prognosis; may be any B or T subgroup | L2 lymphoblast |
| mature B cells; rare occurrence; occurs in both children and adults; poor prognosis | L3 lymphoblast |
| cells typically small, homogeneous and rare indistinct nucleoli. Scant cytoplasm and occasional nuclear clefting present | L1 |
| morphologic variation common in both nuclear chromatin and amount of cytoplasm. moderate to abundant dark blue cytoplasm and nucleus with prominent nucleoli | L2 |
| cytoplasm dark blue and highly vacuolated | L3 |
| immature T and B cells stain positively with | TdT |
| another name for mature B or L3 | Burkitts |
| CSF involvement is more common in patients with | acute lymphocytic leukemia |
| ALL L3 lymphoblasts stain with what cytochemical stain | Oil Red O |
| increased plasmacytoid lymphs in the bone marrow is a characteristic of | waldenstroms |
| Mott cells and flame cells are characteristic of patients with | multiple myeloma |
| increased IgM and increased serum viscosity is present in patients with | waldenstroms |
| the type of anemia associated with CLL | hemolytic, autoimmune |
| lymphs with highly folded, dark, clumped nuclei are seen in patients with | Sezary syndrome |
| smudge cells and small lymphs are characteristic of patients with | CLL |
| A condition that involves T cell proliferation | Sezary |
| what is happening during the lymphocytoid phase of CLL | transformation from B cell to plasma cell |
| why is the ESR increased in MM patients | rouleaux |
| what 4 CD markers are common to the precursor T and mature T cells | CD2, CD3, CD5, CD7 |
| which T cell group is positive for either CD 4 or CD 8 | mature |
| what marker is specific for mature B cell ALL | sIg |
| what cytoplasmic marker is specific for immature B cell ALL | TdT |
| What is the PAN marker for the B cell lineage | CD19 |
| which FAB class is TdT negative | L3 |
| which immunologic classification of ALL has a positive sheep erythrocyte antigen | ALL T cell |
| what is the sheep erythrocyte antigen CD marker | CD2 |
| ALL is PAS block | positive |
Created by:
MamaDaBess
Popular Science sets