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chapter 17


cytoplasmic fragments of megakaryocytes platelets
platelets are cytoplasmic fragments of ______ magakaryocytes
true or false: normal platelet count is 150,000-400,000 ml of blood true
the function of platelets is to form temporary platelet plug that helps seals break in _______ blood vessels
circulating platelets are kept inactive and mobile by _____ and prostacyclin from endothelial cells lining blood vessels nitric oxide
platelet formation is regulated by ________ thrombopoietin
true or false: platelets age quickly and degenerate in about 10 days true
hemostasis, the fast series of reaction for stoppage of bleeding requires ______ and substances released by platelets and injured tissues clotting factors
platelets stick to ______ that are exposed when vessel is damaged collagen fibers
why don't platelets stick to intact vessel walls because collagen is not exposed
secreted by endothelial cells that act to prevent platelet sticking prostacyclins and nitric oxide
what chemical messengers are released by activated platelets? ADP and serotinin
chemical messenger released by activated platelets causes more platelets to stick and release their contents ADP
chemical messenger released by activated platelets enhances vascular spasm and platelet aggregation serotonin and thromboxane A2
why is platelet formation an example of positive feedback cycle? as more platelets stick, they release more chemical, which cause more platelets to stick and release more chemicals
reinforces platelet plug with fibrin threads coagulation
effective in sealing larger vessel breaks blood clots
during coagulation _____ is transformed from liquid to gel blood
disorder of hemostasis that results in undesirable clot formation thromboembolic disorder
disorder of hemostasis abnormalities that prevent normal clot formation bleeding disorders
involves both thromboembolic and bleeding disorders disseminated intravascular coagulation
clot that develops and persists in unbroken blood vessel may block circulation, leading to tissue death thrombus
thrombus freely floating in bloodstream embolus
embolus obstructing a vessel embolism
pulmonary or cerebral emboli would be an example of which bleeding disorder embolism
risk factors: atherosclerosis, inflammation, slowly flowing blood or blood stasis from immbolity thrombi and emboli
thrombocytopenia, a bleeding disorder is characterized by a deficient number of _______ circulating platelets
thrombocytopenia is due to suppression or destruction of ______ red bone marrow
impaired liver function: inability to synthesize ______ (clotting factors) procoagulants
causes of ______ include vitamin K deficiency, hepatitis, or cirrhosis impaired liver function
liver disease can also prevent liver from producing _____, which is needed to absorb fat and vitamin K bile
symptoms include prolonged bleeding, especially into joint cavitites hemophilia
widespread clotting occurs in intact ______, blocking blood flow blood vessels
disseminated intravascular coagulation
_____ antigens are referred to as agglutinogens because they promote agglutination RBC
humans have at least _____ naturally occurring RBC antigens 30
erythroblastosis fetalis only occurs in Rh- mom with _____ fetus Rh+
true or false: during secondary pregnancy, Moms anti-Rh antibodies can cross placenta and destroy RBCs of Rh+ baby true
Created by: alexx0593