Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
CH 45
Calcium Channel Blockers
| Question | Answer |
|---|---|
| CCB have their greatest effects on: | the heart and blood vessels |
| What are CCBs used to treat? | - hypertension - Angina pectoris - cardiac dysrhythmias |
| Critical Role that CCB play? | - function of vascular smooth muscle (VSM) |
| CCBS act selectively on? | - peripheral arterioles and arteries - no effect on veins |
| Nifedipine | - works on arterioles |
| verapamil & diltiazem | - works on arterioles AND heart |
| Verapamil | - blocks ca channel in blood vessels and in the hearts |
| Verapamil uses: | - angina (widely used) - essential hypertension (2nd line agent after Thiazide diuretics) - cardiac dysrhythmias (given IV) |
| 5 direct effects of Verapamil: | 1. Decrease of AV nodal conduction (most important**) 2. blockade at peripheral arterioles causing dilation and reducing arterial pressure 3. Block at arterioles and arteries of heart to increase coronary perfusion 4 & 5 |
| Indirect (reflex) effect of Verapamil | - lowers blood pressure which activates baroreceptor reflex |
| Does Verapamil have net effect on the heart? | NO |
| Verapamil administration | - given orally or IV |
| Verapamil ADVERSE EFFECTS | - CONSTIPATION ** Most common - bradycardia - Gingival hyperplasia - Chronic eczematous rash |
| Verapamil food and drug interactions | - Digoxin - Beta Blockers - Grapefruit Juice |
| What is used to remove Verapamil from the GI tract in toxicity? | - gastric lavage followed by activated charcoal |
| DILTIAZEM | - Blocks ca channels in heart and vessels like Verapamil - used for angina, essential hypertension, cardiac dysrhythmias |
| DILTIAZEM side effects: | - less constipation than Verapamil most common: - dizziness - flushing - headache - edema of ankles and feet -Chronic eczematous rash |
| DILTIAZEM food and drug interaction | - beta blockers - digoxin - grapefruit juice |
| NIFEDIPINE | - Works on arterioles but NOT the heart |
| Indirect effects of NIFEDIPINE | - Activated baroreceptor reflex (reflex occurs mainly with IMMEDIATE-RELEASE formulation of Nifedipine) |
| SAFETY ALERT NIFEDIPINE** | - Immediate release has been associated with increased mortality in patients with MI & unstable angina |
| NET EFFECTS OF NIFEDIPINE | 1. lowers BP 2. Increases HR 3. Increases contractile force |
| NIFEDIPINE uses: | - Angina - Hypertension - Suppress preterm labor |
| NIFEDIPINE adverse effects: | - Reflex tachycardia**:combine with beta blocker to prevent - flushing, dizziness, headache, peripheral edema, gingival hyperplasia |
| NIFEDIPINE drug interactions | - Beta blockers (although used for relex tachycardia) - Toxicity can occur |
Created by:
KristinL
Popular Nursing sets