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Pur/Pyr Synth
Med 1
Fuck is it? | Fuck it do? |
---|---|
Carbamoyl Phosphate Synthetase2 | CO2+Glutamine+ATP-->Carbamoyl Phosphate, regulatory enzyme in euks, allosterically inhibited by UTP, allosterically activated by PRPP |
Ribonucleotide Reductase | UDP-->dUDP, inhibited by dATP, activated by ATP, blocked by Hydroxyurea, requires Thioredoxin as co-factor |
Thymidylate Synthase | dUMP-->dTMP, blocked by 5-Fluorouracil |
Dihydrofolate Reductase | DHF-->THF, blocked by Methotrexate(euk)/ Trimethoprim(prok)/ Pyrimethamine(protozoal) |
PRPP Synthetase | R5P-->PRPP, uses ATP, allosterically inhibited by AMP/ADP/GMP/GDP |
PRPP Amidotransferase | PRPP-->5Phosporibosylamine, gives off glutamate, catalyzes rate-limiting step, allosterically inhibited by AMP/GMP/IMP, activated by PRPP |
IMP Dehydrogenase | IMP-->GMP, inhibited by GMP |
Adenylosuccinate Synthase | IMP-->AMP, inhibited by AMP |
Adenosine Deaminase | Adenosine-->Inosine, deficiency=severe combined immunodeficiency[SCIDs] where pt will lack both B&T cell function and will see a build up of dATP= inhibits Ribonucleotide Reductase |
Xanthine Oxidase | Hypoxanthine&Guanine-->Xanthine-->Uric Acid, blocked by Allopurinol |
Hypoxanthine Guanine Phosphoribosyltransferase HGPRT | Hypoxanthine/Guanine-->IMP/GMP, near complete deficiency= Lesch Nyhan Syndrome and will see Hyperuricemia b/c of increased catabolism |