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TCA/ETC/Glyco
Med 1
| Fuck is it? | Fuck it do? |
|---|---|
| Hexokinase | Glucose-->G6P, inhibited by G6P, uses 1 ATP |
| Glucokinase | Glucose-->G6P in liver/pancreatic beta cells, inhibited by F6P but can be over powered by high amounts of glucose, uses 1 ATP |
| PFK2 | F6P-->F2.6BP, activated by insulin, uses 1 ATP |
| PFK1 | F6P-->F1.6BP, Rate limiting step for Glyco, glucose now committed, inhibited by high amounts of citrate/ATP, activated by high amounts of AMP/F2,6BP, uses 1 ATP |
| Phosphoglycerate kinase | 1,3Bisphosphoglycerate-->3Phosphoglycerat, performs substrate level phosphorylation (makes ATP) |
| Pyruvate Kinase | PEP-->Pyruvate, activated by F1,6BP, inhibited by ATP/alanine, performs substrate level phosphorylation (makes ATP), 2nd most common genetic def to cause hemolytic anemia |
| Lactate Dehydrogenase | Pyruvate-->Lactate, used when low O2 or when need more NAD+ |
| Pyruvate Dehydrogenase | Pyruvate-->AcetylCoA, inhibited by ACoA, activated by insulin in liver, in brain/nerves does not respond to hormones, requires TLCFN, performs oxidation reduction |
| Isocitrate Dehydrogenase | Isocitrate-->A.Keto, Most important in TCA b/c highly regulated, inhibited by ATP/NADH, allosterically activated by ADP, performs oxidation reduction, generates NADH= 3 ATP for TCA |
| Alpha-Ketogluterate Dehydrogenase | A.Keto-->SuccinylCoA, Requires TLCFN, performs oxidation reduction and gives NADH = 3 ATP, inhibited by arsenite, succinyl CoA, NADH, Activated by Ca++ |
| SuccinylCoA Synthetase | SuccinylCoA-->Succinate, performs substrate level phosphorylation (makes GTP), generates 1ATP for TCA |
| Succinate Dehydrogenase | Complex 2, Succinate-->Fumerate in TCA, functions in inner mito membrane, performs oxidation reduction, inhibited by malonate, generates FADH2= 2 ATP for TCA, plucks e- off FADH2 for ETC |
| Malate Dehydrogenase | Malate<-->Oxaloacetate, performs oxidation reduction, generates NADH = 3 ATP for TCA |
| NADH Dehydrogenase | Complex 1, proton pump in ETC, plucks e- off NADH for chain, inhibited by Barbiturates and Rotenone |
| Cytochrome b/c1 | Complex 3, proton pump in ETC, inhibited by Antimycin |
| Cytochrome a/a3 (oxidase) | Complex 4, transfers e- to O2, can be bound by both cyanide and CO |
| F0/F1 | ATP synthase complex, performs Oxidative Phosphorylation |
| Enolase | 2Phosphoglycerate<-->PEP, inhibited by fluoride |
Created by:
JustinCo
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