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TCA/ETC/Glyco

Med 1

Fuck is it?Fuck it do?
Hexokinase Glucose-->G6P, inhibited by G6P, uses 1 ATP
Glucokinase Glucose-->G6P in liver/pancreatic beta cells, inhibited by F6P but can be over powered by high amounts of glucose, uses 1 ATP
PFK2 F6P-->F2.6BP, activated by insulin, uses 1 ATP
PFK1 F6P-->F1.6BP, Rate limiting step for Glyco, glucose now committed, inhibited by high amounts of citrate/ATP, activated by high amounts of AMP/F2,6BP, uses 1 ATP
Phosphoglycerate kinase 1,3Bisphosphoglycerate-->3Phosphoglycerat, performs substrate level phosphorylation (makes ATP)
Pyruvate Kinase PEP-->Pyruvate, activated by F1,6BP, inhibited by ATP/alanine, performs substrate level phosphorylation (makes ATP), 2nd most common genetic def to cause hemolytic anemia
Lactate Dehydrogenase Pyruvate-->Lactate, used when low O2 or when need more NAD+
Pyruvate Dehydrogenase Pyruvate-->AcetylCoA, inhibited by ACoA, activated by insulin in liver, in brain/nerves does not respond to hormones, requires TLCFN, performs oxidation reduction
Isocitrate Dehydrogenase Isocitrate-->A.Keto, Most important in TCA b/c highly regulated, inhibited by ATP/NADH, allosterically activated by ADP, performs oxidation reduction, generates NADH= 3 ATP for TCA
Alpha-Ketogluterate Dehydrogenase A.Keto-->SuccinylCoA, Requires TLCFN, performs oxidation reduction and gives NADH = 3 ATP, inhibited by arsenite, succinyl CoA, NADH, Activated by Ca++
SuccinylCoA Synthetase SuccinylCoA-->Succinate, performs substrate level phosphorylation (makes GTP), generates 1ATP for TCA
Succinate Dehydrogenase Complex 2, Succinate-->Fumerate in TCA, functions in inner mito membrane, performs oxidation reduction, inhibited by malonate, generates FADH2= 2 ATP for TCA, plucks e- off FADH2 for ETC
Malate Dehydrogenase Malate<-->Oxaloacetate, performs oxidation reduction, generates NADH = 3 ATP for TCA
NADH Dehydrogenase Complex 1, proton pump in ETC, plucks e- off NADH for chain, inhibited by Barbiturates and Rotenone
Cytochrome b/c1 Complex 3, proton pump in ETC, inhibited by Antimycin
Cytochrome a/a3 (oxidase) Complex 4, transfers e- to O2, can be bound by both cyanide and CO
F0/F1 ATP synthase complex, performs Oxidative Phosphorylation
Enolase 2Phosphoglycerate<-->PEP, inhibited by fluoride
Created by: JustinCo