Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Cytoskeleton Liu
UCI SOM Liu
| Question | Answer |
|---|---|
| Kinetics of f-actin polymerization | nucleation is slow, elongation is fast |
| Critical concentration | minimal G-actin concentration for actin polymerization |
| Barbed end characteristics | + end, lower critical conc., higher polymerization rate, polymerizes at steady state |
| Pointed end | - end, higher critical conc., slower polymerization rate, depolymerizes at steady state |
| Actin-monomer-binding proteins | thymosin and profilin |
| Thymosin | binds actin and inhibits f-actin polymerization |
| Profilin | promotes polymerization of actin |
| Listeria monocytogenes | intracellular parasite that uses profilin |
| Arp2 and Arp3 | form ARP complex; very similar structure to plus end of actin; catalyze polymerization; starts side chains |
| Actin severing and/or capping proteins | villin (from intestine) and gelsonin (from macrophages) |
| Platelet formation | Ca2+ activates gelsonin severs actin filaments which then grow rapidly into many long actin filaments |
| f-actin cross-linking proteins | spectrin (long), fimbrin (short), alpha actinin (medium), flimanin (for cross linking f-actin), dystrophin |
| microvilli components | f-actin, villin, fimbrin, mysoin-I, calmodulin |
| how does the actin-spectrin cytoskeleton network connect to the membrane in RBCs | ankyrin connects to band3 protein, band4.1 protein and adducin connect to glycophorin, an integral membrane protein |
| how does the cortical actin network connect to the membrane in platelets | actin-spectrin network linked to an anion transporter; second- actin-filamin gel achored to glycoprotein Ib-IX |
| duchenne’s muscular dystrophy | lack dystrophin, a spectrin related protein |
| all myosins have what | head, neck, and tail domains with distinct fxns |
| muscle type of myosin | II |
| myosin II makeup | 2 heavy chains and 4 light chains |
| z disc | where the actin filaments join in anti-parallel action (end of sarcomere) |
| 3 most notable actin/myosin structures | contractile ring, stress fibers, adhesion belt |
| myosin I | move vesicles around the cell and attach to the plasma membrane |
| myosin V | vesicular transport of secretory vesicles |
| microtubules are made of what | tubulin heterodimer (alpha and beta tubulin) |
| how many protofilaments in one microtubule | 13 |
| 4 places microtubules are found | cilia/flagella, cytoplasmic microtubules in interphase cells, mitotic spindle, centrioles/MTOC |
| cilia use what form of microtubule | axoneme |
| axoneme structure | 9 doublet microtubules and 2 single microtubules |
| ciliary dynein | move toward the minus end but because of linking proteins, the cilia just bend |
| basal body structure | nine sets of triplet microtubules; same structure as centriole |
| MTOC | microtubule organization center; stimulate polymerization; positive end is away from MTOC |
| Centrosome | single major MTOC |
| Centriole | a pair in the centrosome; same structure as basal bodies; L-shaped configuration; move to different poles during mitosis |
| Gamma-tubulin | base of centrosome; alpha and beta tubulin add on top |
| In a dividing cell, the MTOC is called | spindle pole |
| GTP cap | hydrolysis lags polymerization |
| 2 classes of microtubules | ones with a GTP cap are favored for growth, those without are favored for disassembly |
| if a microtubule loses its GTP cap, what happens | catastrophic depolymerization |
| kinesin | many types, moves to the plus end (away from MTOC)=anterograde |
| dynein | moves to minus end (to MTOC)=retrograde; mitosis |
| polar microtubule | cross linking microtubules in mitosis that don’t bind chromosomes |
| kinetochore MT | MT that grab chromosomes |
| the movement of chromosomes to the poles is known as | anaphase A |
| the poles are pushed and pulled apart in what phase | anaphase B |
Created by:
droid
Popular Biology sets