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Ch 33

Drugs for Inflammation and Fever

Define Histamines. Key chemical mediators of inflammation stored in mast cells. Histamines dilate blood vessels causing the capillaries to become more permeable. *a large amount of these chemical mediators can cause anaphylaxis
What are NSAID's? Used for mild to moderate pain, inflammation, and fever. These block COX-1 and COX-2.
Aspirin is.. Both COX-1 and COX-2
Ibuprofen (Advil, Motrin) is .. Both COX-1 and COX-2
NSAID'S cause what adverse effects? Nausea, heartburn, epigastric pain, dizziness, ulcers
Celecoxib (Celebrex) is... COX-2 inhibitor
What are adverse effects of NSAID's? Stomach pain, heartburn, nausea, vomiting, tinnitus
NSAID's cause undesired effects especially____? Damaging the lining of your stomach.
Some NSAID's are given with a drug that protects the gastric mucosa including: Naproxen with esomeprazole. (Vimovo) for heartburn Ibuprofen with famotidine (Duexis) for gastric ulcers
What are corticosteroids? When inflammation becomes more severe. They suppress the release of histamine and inhibit functions of phagocytes and lymphocytes.
What are adverse effects of prednisone? Cushing's syndrome, hyperglycemia, fat redistribution,ulcers
Name a corticosteroid. Betamethasone
What are adverse effects of tylenol? Nausea, vomitting, chills, fatal, hepatic necrosis, or liver damage
Long term therapy of corticosteroids can lead to____ Cushing's syndrome
What is cushing's syndrome? A noncancerous tumor of the pituitary gland, located at the base of the brain, that securities an excess amount of ATCH, which in turn stimulates the adrenal gland to make more cortisol.
Patients with this syndrome usually have excess weight gain and fatty deposits around the face. Cushing's syndrome
What are anitpyretics? Drugs used to treat fever, and lower body temperature. Most fevers are caused by infectious processes, drugs themselves may be the cause.
What is an anti-infective: Most common to induce fever (amphotericin B or Penicillin G)
What is an SSRI? (Drug induced fever) Selective serotonin reuptake inhibitors: paroxetine (paxil) for depressions and mood swings may cause serotonin syndrome.
What effect do conventional antipsychotic drugs have? (Drug induced fever)chlorpromazine(Thorazine) produces elevated temperature with cardiovascular and respiratory distress
What effect does volatile anesthetics and depolarizing neuromuscular blockers have (Drug induced fever) can cause malignant hyperthermia
What effect does an immunimodulators have? (Drug induced fever) may cause flulike syndrome
Created by: alyxinwndrland