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Pharm def ch 19

HCC Pharm def ch 19 - Cholinergic Drugs

QuestionAnswer
Acetylcholine (ACh) Neurotransmitter responsible for transmission of nerve impulses to effector cells in the parasympathetic nervous system (PSNS). (p. 297
Acetylcholinesterase (AChE) Enzyme responsible for the breakdown of ACh (also referred to simply as cholinesterase). (p. 298)
Alzheimer's disease A disease that is characterized by progressive mental deterioration manifested by loss of memory, ability to calculate, and visual-spatial orientation, as well as by confusion and disorientation, (p. 298)
Cholinergic drugs Drugs that stimulate the PSNS by mimicking ACh. (p. 298)
Direct-acting cholinergic agonists Cholinergic drugs that bind directly to cholinergic receptors to activate them, (p. 298)
Indirect-acting cholinergic agonists Cholinergic drugs that work indirectly by making more ACh available at the receptor site. (p. 298)
Irreversible cholinesterase inhibitors Drugs that form a permanent covalent bond with cholinesterase. (p. 298)
Miosis Contraction of the pupil, (p. 298)
Muscarinic receptors Effector-organ cholinergic receptors located postsynaptically in the smooth muscle, cardiac muscle, and glands supplied by parasympathetic fibers; so named because they can be stimulated by the alkaloid muscarine, (p. 297)
Nicotinic receptors Cholinergic receptors located in the ganglia (where presynaptic and postsynaptic nerve fibers meet) of both the PSNS and the sympathetic nervous system; so named because they can be stimulated by the alkaloid nicotine, (p. 297
Parasympathomimetics Another name for cholinergic drugs that mimic the effects of ACh. (p. 298)
Reversible cholinesterase inhibitors Drugs that bind to cholinesterase for minutes to hours but do not form a permanent bond. (p. 298)
Created by: laura999
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