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Immunology FOM

QuestionAnswer
What are the functions of IL-1 Activation of T helper 0 and vascular endothelium. Causes Inflammation
What are the functions of IL-2 Proliferation of T cells
What are the functions of IL-3 Growth of hematopoeitic progenitors, Activation of B cells
What are the functions of IL-4 Activation of B cells, Ig class switching to IgG 1&3 and IgE, required for survival of T cells, differentiation of Th0 to Th2, anti-inflammatory
What are the functions of IL-5 Promote growth and differentiation of eosinophils, enhancement of of IgE, IgG1, IgA, IL-9, and IL-10
What are the functions of IL-6 Growth and differentiation fo T and B cells, enhancement of IgA production, stimulation of ACUTE PHASE PROTEIN production
What are the functions of IL-8 Chemotaxis of neutrophils and T cells
What are the functions of IL-9 Maturation of mast cell activity
What are the functions of IL-10 Inhibition of macrophage IL-1 production, ANTI-INFLAMMATORY
What are the functions of IL-12 Induction of interferon gamma by T and NK cells
What are the functions of IL-13 IL-4 like, ANTI-INFLAMMATORY
What are the functions of IL-15 IL-2 like growth, differentiation of NK T cells and gamma-delta T cells
What are the functions of IL-18 Enhancement of IL-12 induction of interferon gamma
What are the functions of interferon gamma Activation of macrophages, upregulation of MHC
What are the functions of TNF-alpha Activation of macrophages, induction of nitric oxide, activation of vascular endothelium
What are the functions of LT(TNF-beta) Activation of macrophages, induction of nitric oxide
What are the functions of GM-CSF Production of myeloid cells
What are the functions of TGF-beta Inhibition of B cell growth and macrophage activation, switch for B cells to produce IgA, ANTI-INFLAMMATORY
What antigens does TLR2 and TLRX recognize Lipoproteins, peptidoglycan, and zymosan
What antigens does TLR3 recognize Double stranded RNA
What antigens does TLR4 recognize LPS, HSPs, and Taxol
What antigens does TLR5 recognize Flagellin
What antigens does TLR7 recognize Imidazoquinolines (and viral compounds)
What antigens does TLR9 recognize Bacterial DNA (CpG DNA)
What cluster of differentiation is specific for T helper cells and what MHC does the cell recognize CD4; recognizes MHC-II
What cluster of differentiation is specific for cytotoxic T cells and what MHC do they recognize CD8; recognize MHC-I
What cluster of differentiation is specific for all T cells CD3
What are the properties of IgM Pentamer, 10 binding sites, very strong activator of complement, naive B cell antigen receptor
What are the properties of IgA Secreted, monomer or DIMER, functions as mucosal immunity, and passive neonatal immunity
What are the properties of IgD monomer, naive B cell antigen receptor
What are the properties of IgE monomer, causes mast cell activation (immediate hypersensitivity)
What are the properties of IgG monomer, opsonin, complement activator, Ab dependent cell mediated cytotoxicity, neonatal immuninity, feedback inhibition of B cells
What are the three pathways of complement activation Classical (Ab required), Alternative (High levels of Ag), and Lectin (Lectin binding to Mannose binding receptors)
Where is MHC-I expressed On all nucleated cells of the body
Where is MHC-II expressed On all professional Antigen Presenting Cells
Explain the invariant chain and the CLIP The invariant chain, especially the CLIP portion, is a structure that binds to MHC-II to keep it from reacting to self-antigen. HLA-DM facilitates the release of CLIP when a foreign Ag is nearby so that the MHC-II molecule will present Ag to B and T cells
What are the signs of inflammation redness, swelling, heat, and pain
Pro-inflammatory cytokines produced by macrophages IL-1, IL-8, IL-6, IL-12, IL-18 (liver), TNF-alpha, IFN-gamma
Triggers of apoptosis Withdrawal of growth hormones, Receptor-ligand interactions, Injury, Bcl-2
Regulators of apoptosis Bcl-2 family members, pro-apoptotic molecules, p53, cytochrome c, Protein Smac/Diablo, Apoptosis inducing factor, Endonuclease
Executioners of apoptosis Executioner capsases (capsase 9 and 3)
What are the mechanisms of Ag Receptor Diversity Somatic recombination, mRNA splicing, Junctional diversity
Created by: Aryals