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cells and tissues 2
c&t
| Question | Answer |
|---|---|
| Coomponents of the ECM | Amorphous ground substance and Fibers |
| What type of fibers make up the fibers portion of the ECM | collagen and elastic |
| Participates in Signal transduction,maintenance of cell shape , cell developement, holds water and other molecules | ECM |
| Glycosaminoglycans | Have a strongly negative charge because of sulfate and carboxyl |
| All GAG's are generally linked to a core protein, what is the exception? | Hyaluronic Acid |
| Where the GAG is present, what type of matrix exists? | hydrated |
| Is the matrix formed resistant or not to compression? | resistant |
| What does the matrix compression do? | squeezes out fluids, but quickly returns to swollen state once the force is released |
| What are the four main groups of GAGs? | Hyaluronic Acid, Chondroitin &Dermatin Sulfate, Heparin sulfate, Keratin |
| Important in vasculature | Heparin sulfate |
| Are composed of protein + GAG's | Proteoglycans |
| Has a bottle brush appearance | Proteoglycans |
| proteoglycans are joined to hyaluronic acid chains | in cartilage |
| multifuntional binding sites | fibronectin |
| mediates overall cell adhesion | Fibronectin |
| "Arms" binding sites for cell surface receptor called integrin, heparin sulfate, type IV collagen and inactin | Laminin |
| Enactin functions | sulfated adhesive glycoprotein, links laminin with type IV collagen and linkage is in lamina densa |
| Are transmembrane protein that link all of teh components of ECM to PM | Integrins |
| Consists of two polypeptides | Integrins |
| Integrin binds to what on the extracellular leaflet of PM | Integrin |
| Actin proteins that Integrin interacts with | Talin, Vinculin, Cappins protein, alpha actinin |
| The most abundant structural protein of the ECM | Collagens |
| Long rigid triple helical strcture woven around each other in a right handed helix | Collagen molecule |
| Collagen | rich in prolin and glycine, every third residue is glycin |
| What does adding sugar to a protein do | makes it more stable |
| Which vitamin is required for collagen synthesis | Vitamin C |
| Which type collagen assembles into a meshwork (lamina densa) | Type IV |
| Which type collagen forms long fibers (fribrillar) | Type I |
| Has high tensile strength | Type I collagen |
| Present mainly in hyaline and elastic cartilage | Type II |
| Type of collagen that has very thin fibrils | Type II |
| Type III Collagen | major component of reticular fibers and associated with type I in tissues |
| Found exclusively in lamina densa | Type IV collagen |
| Imparts elasticity to ECM | elastin |
| Desmosine | what elasticity is due to |
Created by:
chrey23
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