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Bacterial Disease
Microbiology, Bacterial Diseases
| Question | Answer |
|---|---|
| boils, pimples, abscesses | skin; Staph aureus, Staph epidermidis; can develop into bacteremia, TSS |
| impetigo | skin; Strep pyogenes; treatment is hygeine, topical mupirocin; M protein anti-phagocytosis; Streptokinase dissolve blood clots, Hyaluronidase dissolve tissue cement |
| Pseudomonas infection | skin; Pseudomonas aeruginosa; burn patients and geriatrics; produces pyocyanin green toxin; coinfection w/ C. perfringins; can lead to gas gangrene |
| acne | skin; Propionibacter acnes |
| bacterial meningitis | NS; Hemophilis influenzae, Neisseria meningitidis, Strep pyogenes |
| listerosis | NS; Listeria monocytogenes; grows 4 degrees C, pregnant women, cancer patients, poultry and dairy |
| tetanus | NS; Clostridium tetani; lockjaw, spasmotic paralysis; wound infection; part of DPT vaccination |
| botulism | NS; Clostridium botulinum; toxin type A (USA), B (European), E (seafood); flaccid paralysis; Botox |
| leprosy | NS; Mycobacterium leprae; acid fast; peripheral nerves; not very contagious and requires long & intimate contact; cultivated in armadillos |
| bacteremia | presense of bacteria in blood |
| septicemia | blood poisoning; pathogens typically do not grow in blood (lymphocytes and low Fe+3) |
| lymphangitis | inflammation of lymph nodes |
| sepsis | toxic conditions from septicemia |
| septic shock | endotoxin; 1 millionth of a gram |
| Toxemia | presense of toxins in blood (i.e. as occurs in tetanus) |
| peripheral fever | CV system; disease of childbirth (Semmelweis, 1840's)disinfectant procedures; Strep pyogenes |
| endocarditis | CV system; acute = Staph aureus; inflammation of inner heart lining, destruction of heart valves |
| rheumatic fever | CV system; repeated infections of Strep pyogenes (strep throat); 4-18 yr olds; joint pain nodule and lumpy joints; M protein antigens, antibody response damages heart |
| tularemia | CV system; Franciella tularensis; rabbits & squirrels; small ulcers at primary site; ID50 = 10 organisms, survives in phagocyte |
| brucellosis | CV system; Brucella abortus; cattle/swine, secreted in milk, milk products/direct contact; infects uterus, undulating fever rises in evening 104 F; survives phagocytes, grows intracellulary |
| anthrax | CV system; Bacillus anthracis; sporeformer; long chains with squared ends; direct contact, wool, aerosol-spores; cutaneous- black necrotic dying center; inhalation- pulmonary form most severe; capsule, exotoxin |
| gas gangrene | CV system; Clostridium perfringens; sporeformer; death of soft tissue; seen in diabetics; toxin travels down muscle bundles; Pseudo aeruginosa coinfection; amputation, maggots, hyberbaric O2 |
| plague | vector- rat fleas; Ysernia pestis, "Black Death" Bubonic Plague (bubos formation),pneumonic form spread person-person |
| relapsing fever | vector- soft ticks; Borrelia recurrensis (or hermsii); patient recovers and fever reappears due to surface antigens changing |
| lyme disease | vector- hard ticks; Borrelia burgdorferi; spirochete; rodent reservior, deer in lifecycle; "Bull's Eye" rash, later stages similar to syphilis heart neuro involvement, arthritis |
| endemic typhus | vector- body louse; Rickettsia prowazekii; louse gut growth excreted in feces; host scratches rubs in feces; high prolonged fever severe headache; killed Anne Frank |
| rocky mountain spotted fever | vector- ticks; Rickettsia rickettsii; rash appears 1st on palms, soles then entire body; mistaken for measles; kidney & heart failure |
| Streptococcal pharyngitis | respiratory; Strep pyogenes; can lead to otidis media; M protein makes resistant to phagocytosis |
| scarlet fever | respiratory; Strep pyogenes; erythrogenic toxin produces small red "goose bumps" entire body EXCEPT face, palms, soles |
| diphtheria | respiratory; Corynebacterium diphtheriae; club shaped/chinese characters; toxin inhibits protein syn; produces pseudomembrane at back of throat; part of DPT vaccine |
| otidis media | respiratory, earache; Strep pneumoniae (35%), Hemophilis influenzae (20-30%), Mycoplasma catarrhalis (10-15%), Strep pyogenes (8-10%), Staph aureus (1-2%) |
| pertussis (Whooping Cough) | respiratory; Bordetella pertusis; capsulated, destroys cilary cells; part of DPT vaccine |
| tuberculosis (consumption) | respiratory; Mycobacterium tuberculosis; acid fast; enters lungs -> alveoli; MAIS, AIDS patients |
| Legionaires disease | respiratory; Legionella pneumophila; naturally occurring in water, resistant to chlorine; high fever and pneumonia symptoms |
| bacterial pneumonias | respiratory; Strep pneumoniae (lung fluid, capsulated), Hemophilis influeniae, Mycoplasma pneumoniae (fried egg appearance, "walking pneumonia"), Chlamydia pneumoniae (needs ATP, associated w/ atherosclerosis) |
| dental caries | digestive; Strep mutans; requires sucrose to make detrin cement; prevention best |
| peridontal disease | digestive; Treponema denticola (relative of Pallidum); gingivitis -> peridontidis |
| Intoxication | ingesting a toxin |
| Infection | pathogenesis due to organism |
| Staphylococcal poisoning | digestive; Staph aureus; found in custards, cream pies, potato salad, ham; toxin is heat stable |
| Shigellosis (Bacillary Dysentery) | digestive; Shigella dysentariae; cytotoxin Shiga; rarely involves bloodstream; blood & mucosal diarrhea; rehydration treatment |
| Typhoid Fever | digestive; Salmonella typhi; only in humans (i.e. Mary Mallon); 1-3% recovered are carriers colonize in gallbladder |
| Salmonellosis (Salmonella Gastroenteritis) | digestive; Salmonella typhimurium; rehydration treatment |
| Cholera | digestive; Vibrio cholerae; found in water sources, along Gulf, shellfish; "Rice Water" stool, usually no fever; severe dehydration lose of water and electrolytes; rehydration treatment w/ sugar water, electrolytes |
| E. coli gastroenteritis | digestive; E. coli (O157:H7); "Traveler's diarrhea" |
| peptic ulcers | disgestive; Helicobacter pylori; survives in stomach, urea ammonia neutralizes stomach acid; inflammation |
| Leptospirosis | urinary; Leptospira interogans; spirochete; animal reservior- animals shed in urine from infected kidneys; expand/spread in water such as lakes/ponds; infects kidneys and liver |
| Gonorrhoea | reproductive; Neisseria gonorrhoeae; requires extra CO2 for growth, fastidious; females- infects cervix (60-90% infection rate, 60-80% asymptomatic) males- infects urethra (80% infection rate, painful urination, blocks urethra, sterility; AgNO3 neonatal |
| Chlamydia (nongonoccal urethritis) | reproductive; Chlamydia trachomatis; most prevalent STD; 5 x more in females, infects uterine tubes leads to PID, males- epididymis |
| Pelvic inflammatory Disease (PID) | reproductive; N. gonorrhoeae, C. trachomatis, M. hominus, U. urelytica; leads to sterilty & ectopic pregnancy |
| Syphilis | reproductive; Treponema pallidum; spirochete, motile, fastidious; "stealth" pathogen; site of infection = SINGLE painless ulcer; secondary stage appears as rash (contagious)on trunk & spreads to palms and soles; systemic; tertiary 1-20 yrs, not contagious |
| Chancroid | reproductive; Hemophilis ducreyi; ID50 = 1-2 organisms; primary site can include MULTIPLE painful ulcers |
| bacterial vaginosis | reproductive; Candida albicans, Trichomonas vaginalis, Gardnerella vaginalis; normal flora Lactobacillus produces H2O2 keeps other flora supressed; Lactobacillus reduced other take over, cause vaginosis; milky white fluid, foul odor; re-est Lactobacillus |