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Drug profiles

ondansetron, diltiazem, glucagon, nalmefene, vasopressin

QuestionAnswer
Vasopressin GENERIC NAME Vasopressin
Vasopressin BRAND NAME Pitressin synthetic
Vasopressin CLASS Antidiuretic hormone
Vasopressin MECHANISM OF ACTION Stimulation of V1 smooth muscle receptors, potent vasoconstrictor when given in high doses.
Vasopressin INDICATIONS Alternate vasopressor to the first or second dose of epinephrine in cardiac arrest, may be useful in cases of vasodilatory shock
Vasopressin CONTRAINDICATIONS Responsive patients with cardiac disease.
Vasopressin ADVERSE REACTIONS Bronchoconstriction, ischemic chest pain, N/V.
Vasopressin INCOMPATABILITIES/DRUG INTERACTIONS None
Vasopressin DOSE/ROUTE Adult 40 unit one time dose IV/IO to replace the first or second dose of epinephrine in cardiac arrest.
Vasopressin ONSET OF ACTION Immediate
Vasopressin PEAK EFFECTS Variable
Vasopressin DURATION OF ACTION Variable
Vasopressin AZ DRUG BOX SUPPLY RANGE 40 units (optional)
DILTIAZEM GENERIC NAME DILTIAZEM
DILTIAZEM BRAND NAME Cardizem
DILTIAZEM CLASS Calcium Channel Blocker, Calcium antagonist
DILTIAZEM MECHANISM OF ACTION Blocks calcium form moving into the heart muscle cell, which prolongs the conduction of electrical impulses through the AV node.
DILTIAZEM INDICATIONS ventricular rate control in rapid a-fib and a-flutter, and for PSVT refractory to adenosine.
DILTIAZEM CONTRAINDICATIONS Hypotension , heart block, heart failure, Beta Blocker Use
DILTIAZEM ADVERSE REACTIONS hypotension, Bradycardia, heart block, chest pain, and Asystole
DILTIAZEM INCOMPATABILITIES/DRUG INTERACTIONS Avoid use in patients with poison- or drug-induced tachycardia. Calcium chloride can be used to prevent the Hypotensive effects of this drug and treat patients with a calcium channel blocker overdose.
DILTIAZEM DOSE/ROUTE Adult Dosage Initial 0.25 mg/kg IV over 2 minutes If response is inadequate, repeat in 15 minutes 0.35 mg/kg over 2 minutes. Maintenance infusion 5.0 to 15 mg/hr
DILTIAZEM ONSET OF ACTION immediately
DILTIAZEM PEAK EFFECTS 2 hours
DILTIAZEM DURATION OF ACTION 6 hours
DILTIAZEM AZ DRUG BOX SUPPLY RANGE 25 mg
Glucagon GENERIC NAME None
Glucagon BRAND NAME Glucagon
Glucagon CLASS Hyperglycemic agent, insulin antagonist
Glucagon MECHANISM OF ACTION Converts glycogen to glucose
Glucagon INDICATIONS hypoglycemia, beta blocker overdose.
Glucagon CONTRAINDICATIONS Hyperglycemia, hypersensitivity
Glucagon ADVERSE REACTIONS N/V tachycardia, hypertension
Glucagon INCOMPATABILITIES/DRUG INTERACTIONS Incompatible in solution with most other substances.
Glucagon DOSE/ROUTE Adult Hypoglycemia 1mg IM. May repeat in 7-10 minutes.
Glucagon DOSE/ROUTE Adult, beta blocker overdose 5mg over 1 min. second dose of 10mg if symptoms of Bradycardia or hypotension recur.
Glucagon DOSE/ROUTE Pediatric, hypoglycemia 0.5-1mg IM.
Glucagon ONSET OF ACTION 1 minute
Glucagon PEAK EFFECTS 30 minutes
Glucagon DURATION OF ACTION Variable
Glucagon AZ DRUG BOX SUPPLY RANGE 2mg.
NALMEFENE GENERIC NAME NALMEFENE HCl
NALMEFENE BRAND NAME Revex
NALMEFENE CLASS narcotic antagonist
NALMEFENE MECHANISM OF ACTION Competitive inhibition at narcotic receptor sites
NALMEFENE INDICATIONS Opioid overdoses when Naloxone is not available
NALMEFENE CONTRAINDICATIONS Hypersensitivity
NALMEFENE ADVERSE REACTIONS Withdrawal symptoms, N/V, diaphoresis, increased heart rate, v-fib, hypotension or hypertension.
NALMEFENE INCOMPATABILITIES/DRUG INTERACTIONS Should not be mixed with other drugs
NALMEFENE DOSE/ROUTE Adult Dosage IV, IM, and SC
NALMEFENE ONSET OF ACTION 2 minutes
NALMEFENE PEAK EFFECTS Variable
NALMEFENE DURATION OF ACTION 8 hours
NALMEFENE AZ DRUG BOX SUPPLY RANGE 4mg optional
Ondansetron GENERIC NAME Ondansetron
Ondansetron BRAND NAME Zofran
Ondansetron CLASS Antiemetic agent
Ondansetron MECHANISM OF ACTION Selectively blocks serotonin 5-HT3 receptors located in the CNS .
Ondansetron INDICATIONS N/V
Ondansetron CONTRAINDICATIONS Hypersensitivity,Use with caution in patients with hepatic impairment
Ondansetron ADVERSE REACTIONS Headache, dizziness, sedation, Chest pain, arrhythmias
Ondansetron INCOMPATABILITIES/DRUG INTERACTIONS Inducers or inhibitors of P450 drug metabolizing enzymes may alter the clearance of Ondansetron.
Ondansetron DOSE/ROUTE Adult Dosage 4 – 8 mg IV slow push over 2 – 5 minutes
Ondansetron DOSE/ROUTE Pediatric Dosage 0.1 mg/kg IV slow push over 2 – 5 minutes max dose 4mg
Ondansetron ONSET OF ACTION 30 minutes
Ondansetron PEAK EFFECTS unknown
Ondansetron DURATION OF ACTION unknown
Ondansetron AZ DRUG BOX SUPPLY RANGE 8mg
Created by: klindley