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Cardio Drugs Etc

Other Drugs that Didn't Make it

Centrally Acting Sympatholytics Main Use HT
CAS Mech Activate alpha2's in brain stem
CAS Response decrease SNS, CO and TPR
CAS Use Resistant HT
CAS Other Sudden stopping can cause rebound hypertension (bad), use methyldopa in preggers w/HT
Direct Arterial Vasodilators Main Use Hydralazine, works in pretty much everyone, use comboHT
DAV Mech Hydral = ???Minoxidil = K channel agonist (opener)
DAV Response Decrease ateriolar contraction -> decrease TPR, increase SNS, RAS and renal Na retention
DAV Use Hydral in resistant HTMinoxidil = more potent but only in people w/severe refractory HT in renal fail, neither widely used clinically
DAV SE Headaches, dizzy, tachy, edema, hair growth (Minidoxil)
DAV Other both drugs in combo w/diuretic and b-blocker to suppress compensatory pressor mech (good to decrease BP but activate lots of other systems -> leads to physiologic tolerance
Created by: chavezc3



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