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Cellular Respiration

What is substrate level phosphorylation? Transferring a phosphate to an ADP, directly from another molecule
What is oxidative phosphorylation? The production of ATP, is driven by a proton gradient
Where does glycolysis occur? Cytoplasm
Glucose + ATP -> _____ + ADP + H(+) Glucose - 6 - phosphate
What enzyme is used to convert glucose to glucose -6 - phosphate? Hexokinase
What is so significant about G-6-P? Charged molecule which is prevented from leaving the cell
Glucose - 6 - phosphate -> _____ Fructose -6 -phosphate
What enzyme catalyses G-6-P to F-6-P? Phosphoglucose isomerase
Fructose-6-phosphate + ATP -> _______ +ADP + H(+) Fructose 1,6-bisphophate
What enzyme catalyses the conversion of F-6-P to F-1,6-bP? Phosphofructokinase
Fructose -1,6- bisphosphate <-> Glyceraldehyde - 3 - phosphate + _____ Dihydroxyacetone phosphate
Dihydroxyacetone <-> _____ Glyceraldehyde-3-phosphate
Glyceraldehyde-3-phosphate + NAD+ + Pi <-> ____ + NADH + H+ 1,3-bisphosphateglycerate
1,3-bisphosphateglycerate + ADP <-> ______ + ATP 3-phosphateglycerate
3-phosphoglycerate <-> _____ 2-phosphoglycerate
2-phosphoglycerate <-> ____+ H2O Phosphoenolpyruvate
Phosphoenolpyruvate + ADP + H+ -> ___ + ATP Pyruvate
What are the products of glycolysis? 2x Pyruvate 2x ATP (net) 2x NADH
What are the three fates of pyruvate? Lactate Ethanol CO2 and water in oxidative phosphorylation
What inhibits hexokinase? Glucose - 6- phosphate
What activates phosphofructokinase? AMP, ADP & fructose 1,6 - bisphosphate
What inhibits phosphofructokinase? ATP & Citrate
What activates pyruvate kinase? Fructose 1,6- bisphosphate
What inhibits pyruvate kinase? ATP & acetyl CoA
Where does the TCA cycle & link reaction occur? Matrix of the mitochondria
What happens when pyruvate is added to coA to produce acetyl co-enzyme A ? CO2 is lost, and NADH is produced
Oxaloacetate + Acetyl CoA -> ____ Citrate
Citrate <-> ____ Isocitrate
Isocitrate <-> _____ Alpha ketoglutarate
When isocitrate is converted to alpha ketoglutarate, what molecules are produced? CO2 & NADH
Alpha ketoglutarate -> ____ Succinyl CoA
When alpha ketoglutarate is converted to succinyl CoA, what is produced? CO2 and NADH
Succinyl CoA -> _____ + CoA Succinate
What is produced when Succinyl CoA is converted to succinate? ATP/GTP
Succinate <-> _____ Fumurate
What is produced when succinate is converted to fumurate? FADH2
Fumurate <-> ____ Malate
Malate <-> ______ Oxaloacetate
When malate is converted to oxaloacetate, what is produced? NADH
What inhibits citrate synthase? ATP
What inhibits alpha ketoglutarate dehydrogenase complex? ATP and succinyl CoA
What stimulates isocitrate dehydrogenase? NAD+, ATP, Mg2+
What inhibits isocitrate dehydrogenase? ATP, NADH
Where does the electron transport chain occur? Inner mitochondrial membrane
What is special about succinate dehydrogenase in terms of where it is? It is found in complex II
Created by: Jake_Bark