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Micro Lecture

Exam Chapters 13-16

Immunocompetence ability of the body to react with countless foreign substances
Antigens foreign molecules that stimulate an immune response from B and T cells
Specificity and Memory 2 features that characterize the specific immune response
Specific Immunity development and differentiation, antigen presentation, challenge of B and T cells by antigens, T lymphocyte response
B Cells mature in bone marrow
T Cells mature in thymus
When Pathogens Cross The First Line Of Defense macrophages migrate to site, pathogen ingested causing inflammatory response, antigen presented to T and B cells
Major Histocompatibility Complex (MHC) one set of genes codes for human cell markers or receptors
Class 1 Genes code for markers on all nucleated cells, displays self, allow recognition of immune reactions
Class 2 Genes code for immune regulatory markers found on macrophages, dendritic cells, and B cells involved in presentation to T cells
T Cell challenged with Ag, proliferate, and differentiate, and respond through an MHC molecule
Memory T Cells remember prior antigens
Helper T Cells (CD4) activate macrophages, assist B-Cell processes, and help activate cytotoxic T cells. use 2 MHC
Cytotoxic T Cells (CD8) lead to destruction of infected host cells and other foreign cells. use 1 MHC
Regulatory T Cells (Tregs) control T cell response
MHC required for T cell activation
Immunoglobulin means antibody when secreted, serve as antigen receptors of B cells
Antigen Binding Sites pockets in the end of the molecules fork highly variable in shape to fit a wide range of antigens
Variable Regions areas of extreme versatility from one clone to another
Diversity rearrangement of gene segments that code for antigen receptors on T and B cells
Clonal Selection mechanism by which the correct B or T cell is activated by incoming antigen
Lymphocyte Specificity preprogrammed, existing in genetic makeup before antigen has ever entered the tissue
Clonal Expansion rapid multiplication of B or T cell clones after activation by an antigen
Haptens small foreign molecules too small by themselves to elicit an immune response
Alloantigen's cell surface markers and molecules that occur in some members of the same species, but not in others
Superantigen's potent toxins that stimulate T cells, activate T cells at a rate of 100 times greater than ordinary signals
Antigen Presenting Cells (APC's) formally presented to lymphocytes, 3 types: macrophages, B cells, and dendritic cells
T Cell Reactions tell others what to do in immune system
CD4 T Cells critical in regulating immune reactions to antigens
CD8 T Cells kill infected cells
Lack Specificity For Antigens the first killer cells to attack cancer cells and virus infected cells, rogue don't need to be told what to do
Activated B Cell becomes a plasma cell and starts secreting antibodies
Colostrum the very earliest secretion during breast feeding, contains a high amount of IgA
Titer a concentration of antibodies
Natural Immunity immunity acquired through the normal biological experiences of an individual
Artificial Immunity protection from infection obtained through medical procedures such as vaccines and immune serum
Active Immunity receives immune stimulus that activates B and T cells to produce substances such as antibodies
Passive Immunity receives antibodies from another human or animal
Vaccine any immunity obtained by inoculation with selected antigens
Whole Cell Or Virus Vaccines live, attenuated cells or viruses, killed cells or inactivated viruses
Conjugated Vaccines subunits conjugated with proteins to make them more immunogenic
DNA Vaccines microbial DNA is inserted into a plasmid vector and inoculated into a recipient
Created by: MaryMamiChula