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Inflammation

Goljan's Inflammation and Repair

QuestionAnswer
List the sequence of vascular events in Acute Inflammation. Vasoconstriction of arterioles--> Vasodilation of arterioles--> Increased permeability of venules --> Swelling of tissue --> Reduced blood flow
Acute Inflammation : What molecules are responsible for "rolling" of neutrophils? Selectin
Acute Inflammation : What molecules are responsible for Neutrophil adhesion? 1) B2-Integrins (Neutrophil Adhesion Molc), activated by C5a and LTB4 2) ICAM and VCAM (Endothelial Adhesion Molc), activated by IL-1 and TNF
Dx : Delayed seperation of umbilical cord, severe gingivitis, peripheral blood neutrophilic leukocytosis. Leukocyte Adhesion Deficiency -type 1 = deficiency in B2-Integrins (CD11a:CD18) -type 2 = deficiency in selectin
Acute Inflammation : List the mediators for chemotaxis 1) C5a 2) LTB4 3) IL-8 4) Chemokines, bacterial products
Acute Inflammation : List examples of opsonins 1) IgG 2) C3b
Dx : Opsonization defect Bruton's agammaglobulinemia
Dx : Absent NADPH oxidase and absent respiratory burst Chronic granulomatous disease
Dx : Normal respiratory burst, but unable to synthesize bleach. Myeloperoxidase deficiency
Acute inflammation : List the chemical mediators of pain 1) Bradykinin 2) PG E2
Acute inflammation : List the chemical mediators of fever IL-1 and TNF initiate PGE2 synthesis. PGE2 produces pain.
Chronic inflammation : What are the primary leukocytes in chronic inflammation? Monocytes and macrophages
Chronic inflammation : Name the key adhesion glycoprotein in ECM. Fibronectin
Chronic inflammation : What chemical activates macrophages? Interferon-gamma. Activated macrophages form epitheloid cells.
Tissue repair : List the growth factors that cause angiogenesis. 1) Vascular endothelial cell GF (VEGF) 2) Basic fibroblas GF (BFGF)
Tissue repair : Name the key adhesion glycoprotein in Basement Membrane Laminin
Tissue repair : What molecule replace type III collagen with type I collagen? And what is its cofactor? Metalloproteinase (collagenases). Zinc is its cofactor.
Tissue repair : What molecule cross-links points of hydroxylation on alpha chains in collagen? And what is its cofactor? Lysyl oxidase. Copper is its cofactor.
Tissue repair : In primary intention, when does granulation tissue formation peak? Days 4-6
Tissue repair : In primary intention, when does collegenase remodeling occur? Month 1
Tissue repair : In secondary intention, what is responsible for wound contraction? Increased numbers of myofibroblasts
Dx : Raised scars due to excess synthesis of type III collagen Keloids
Tissue repair : What are the key repair cells in the lung? Type II pneumocytes
Tissue repair : In brain injury, there is proliferation of what cells? Astrocytes and microglial cells
Tissue repair : In peripheral nerve transection, what cell is the key cell in reinnervation? Schwann cell
What is the predominant immunoglobulin in : a) Acute inflammation b) Chronic inflammation Acute = IgM Chronic = IgG
What are the clinical use of C-Reactive protein? 1) Marker of necrosis 2) Monitor disease activity
Created by: lemontea88