Help
Options
Didn't know it?
click below
click below
Knew it?
click below
click below
Don't Know
Remaining cards (0)
Know
retry
shuffle
restart
0:00
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Inflammation
Goljan's Inflammation and Repair
| Question | Answer |
|---|---|
| List the sequence of vascular events in Acute Inflammation. | Vasoconstriction of arterioles--> Vasodilation of arterioles--> Increased permeability of venules --> Swelling of tissue --> Reduced blood flow |
| Acute Inflammation : What molecules are responsible for "rolling" of neutrophils? | Selectin |
| Acute Inflammation : What molecules are responsible for Neutrophil adhesion? | 1) B2-Integrins (Neutrophil Adhesion Molc), activated by C5a and LTB4 2) ICAM and VCAM (Endothelial Adhesion Molc), activated by IL-1 and TNF |
| Dx : Delayed seperation of umbilical cord, severe gingivitis, peripheral blood neutrophilic leukocytosis. | Leukocyte Adhesion Deficiency -type 1 = deficiency in B2-Integrins (CD11a:CD18) -type 2 = deficiency in selectin |
| Acute Inflammation : List the mediators for chemotaxis | 1) C5a 2) LTB4 3) IL-8 4) Chemokines, bacterial products |
| Acute Inflammation : List examples of opsonins | 1) IgG 2) C3b |
| Dx : Opsonization defect | Bruton's agammaglobulinemia |
| Dx : Absent NADPH oxidase and absent respiratory burst | Chronic granulomatous disease |
| Dx : Normal respiratory burst, but unable to synthesize bleach. | Myeloperoxidase deficiency |
| Acute inflammation : List the chemical mediators of pain | 1) Bradykinin 2) PG E2 |
| Acute inflammation : List the chemical mediators of fever | IL-1 and TNF initiate PGE2 synthesis. PGE2 produces pain. |
| Chronic inflammation : What are the primary leukocytes in chronic inflammation? | Monocytes and macrophages |
| Chronic inflammation : Name the key adhesion glycoprotein in ECM. | Fibronectin |
| Chronic inflammation : What chemical activates macrophages? | Interferon-gamma. Activated macrophages form epitheloid cells. |
| Tissue repair : List the growth factors that cause angiogenesis. | 1) Vascular endothelial cell GF (VEGF) 2) Basic fibroblas GF (BFGF) |
| Tissue repair : Name the key adhesion glycoprotein in Basement Membrane | Laminin |
| Tissue repair : What molecule replace type III collagen with type I collagen? And what is its cofactor? | Metalloproteinase (collagenases). Zinc is its cofactor. |
| Tissue repair : What molecule cross-links points of hydroxylation on alpha chains in collagen? And what is its cofactor? | Lysyl oxidase. Copper is its cofactor. |
| Tissue repair : In primary intention, when does granulation tissue formation peak? | Days 4-6 |
| Tissue repair : In primary intention, when does collegenase remodeling occur? | Month 1 |
| Tissue repair : In secondary intention, what is responsible for wound contraction? | Increased numbers of myofibroblasts |
| Dx : Raised scars due to excess synthesis of type III collagen | Keloids |
| Tissue repair : What are the key repair cells in the lung? | Type II pneumocytes |
| Tissue repair : In brain injury, there is proliferation of what cells? | Astrocytes and microglial cells |
| Tissue repair : In peripheral nerve transection, what cell is the key cell in reinnervation? | Schwann cell |
| What is the predominant immunoglobulin in : a) Acute inflammation b) Chronic inflammation | Acute = IgM Chronic = IgG |
| What are the clinical use of C-Reactive protein? | 1) Marker of necrosis 2) Monitor disease activity |
Created by:
lemontea88
Popular USMLE sets