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Pharm Test 3

Enalapril Vasotec Ace Inhibitor
Enalapril Indications HTN HF
Enalapril Interactions Other HTN meds = additive Thiazide = increase K loss Increase lithium toxicity NSAIDs= decrease effects = Increase BP
Enalapril CI Hypersensitivity Pregnancy/Lactation BBW= Fetal injury/death
Enalapril SE OTH 1st dose syncope HA/Dizziness LIFETHREATENING: angioedema, neutropenia, agranulocytosis
Nifedipine Procardia CCB
Nifedipine Indications HTN Angina
Nifedipine Interactions Other HTN meds= additive BB= increase risk of HF Increase Dig toxocity Alcohol=syncope Grapefruit juice=enhance absorption= additive Melatonin=counter effects = increase BP/HR
Nifedipine CI Hypersensitivity
Nifedipine SE HA Dizziness Peripheral Edema Flushing *Immediate action forms= reflex tachycardia DC gradually=rebound hypotension
Doxazosin Cardura A Blocker
Doxazosin Indications Urinary Retention--> BPH & HTN
Doxazosin Interactions Other HTN meds= additive Climetidine=increase half life Viagra (phosphodiesterase inhib) = additive
Doxazosin CI Hypersensitivity Hypotensive
Doxazosin SE Dizziness Dyspnea Athenia HA Hypotension Somnolence OTH 1st does phenomenon
Metoprolol Lopressor BB
Metoprolol Indications HTN HF
Metoprolol Interactions Diuretics + antiHTN= mask hypoglycemia NSAID=decrease effect Digoxin= increase risk of bradycardia Oral contraceptives = increase effects
Metoprolol CI Hypersensitivity MI= serious sinus bradycardia HR <45/ SBP <100 Mod-Severe HF Asthma Cardiogenic shock
Metoprolol SE Diminished sexual function Insomnia Unusual weakness/fatigue
Losartan Cozaar ARB
Losartan Indication HTN
Losartan Interactions NSAIDs= decrease K diuretics = increase K Diuretics/ antiHTN= additive Herbal: ephedra, licorice, ginseng= additive
Losartan CI Hypersensitivity Renal/Hepatic impairment K supplements- hyperkalemia Hx of angioedema
Losartan SE HA Dizziness OTH Rash Diarrhea AE= angioedema, acute renal failure, 1st dose phenomenon, fetal toxicity, neonatal mortality
Hydralazine Apresoline Vasodilator
Hydralazine Indication HTN HF
Hydralazine Interactions Other HTN meds= additive NSAID= decrease False coombs test Hawthorn= decrease
Hydralazine CI Angina Rheumatic Heart Dz MI Tachycardia Lupus= worsens Abrupt wd= rebound HTN
Hydralazine SE HA Tachycardia Palpitations Flushing Nausea Diarrhea BB=counteract reflex tachycardia *Na/fluid retenion= serious AE
Furosemide Lasix Loop diuretic
Furosemide Indications HTN HF (if fluid retention present)
Furosemide Interactions Cardiac glycosides (dig)= hypokalemia Corticosteroids, amp B, K depleting drugs = hypokalemia
Furosemide CI Hypersensitivty Anuria Hepatic Coma Severe fluid/electrolyte depletion
Furosemide SE Hypokalemia Dehydration Hypotension OTH *Ototoxicity
Spironolactone Aldactone K sparing diuretic, Aldosterone antagonist
Spironolactone Indications HTN Edema- HF
Spironolactone Interactions Ammonium chloride= acidosis ASA, NSAIDs= decrease Digoxin= decrease effects of dig K supplements, ACE inhibitors, ARBS= hyperkalemia
Spironolactone CI Anuria Renal impairment Hyperkalemia Pregnancy/Lactation
Spironolactone SE Hyperkalemia Women: menstrual irregularities, hirsutism, breast tenderness
Hydrochlorothiazide Microzide Thiazide diuretic
Hydrochlorothiazide Indication HTN Edema-HF
Hydrochlorothiazide Interactions Other HTN med= additive Decrease effectivess of anticoag, sulfonylureas, antidiabetic drugs Cholestryamine and Colestipol= decrease absorption NSAIDS= renal toxicity Corticosteroids, amp B = increase K loss= hypokalemia
Hydrochlorothiazide CI Anuria Hypersensitivity Pre-eclampsia Eclampsia Pregnancy induced HTN
Hydrochlorothiazide SE Na/K imbalances Teach increase K in diet Gout attacks= due to hyperuricemia
Digoxin Lanoxin Cardiac Glycoside
Digoxin Indication HF
Digoxin Interactions Diuretics=hypokalemia= dysrhythmias Ace inhib, spironolactone, ARB= hyperkalemia Positive inotropic drug= additive BB= additive bradycardia Antacids, cholesterol lowering drugs= decrease absorption Ginseng= increase risk of dig tox Ma huang, ephedra
Lisinopril Prinivil Ace Inhib
Lisinopril Indications HTN HF
Lisinopril Interactions NSAIDS= decrease Diuretic= additive K diuretic= hyperkalemia Increase lithium levels= toxicity
Lisinopril CI Hyperkalemia Angioedema Pregnancy
Lisinopril SE Cough HA Dizziness OTH Rash Hyperkalemia Taste disturbances Chest pain N/V/D Angioedema= SERIOUS