click below
click below
Normal Size Small Size show me how
Pathopharm II
Anemia + oncology
Term | Definition |
---|---|
Alkylating Agents treat: | broad-spectrum; Hodginks, lymphoma myloma, breast cancer, ovarian cancer |
Alkylating Agent | Cyclophsphamide (Cytoxan) |
Antimetabolites treat: | choriocarcinoma, sarcoma, leukemia, head, neck, breast, and lung |
Antimetabolite | Methotrexate (Rheumatrex, Trexall) |
Antimetabolite | avoid > 6 months after use |
Antimetabolite types | folic acid analog, purine analog, pyrimidine analogs |
Antitumor Antibiotic treat: | solid tumors of lung, breast, ovary, bladder, leukemia, and lymphoma |
Antitumor Antibiotic | CARDIOTOXIC |
Antitumor Antibiotic | Doxorubicin (Adriamycin) "Red Devil" |
Natural products/Miotic Inhibitors treat: | Hodkins, Non-hodkins lymphoma, leukemia, Kuposis sarcoma, Wilms tumor, bladder, breast |
Natural products/Miotic Inhibitors | NERVOUS SYSTEM TOXICITY (crosses blood brain barrier) |
Natural products/Miotic Inhibitors | Vincristine (Oncovin) |
Hormones + Hormone Antagonist treat: | slow growth of reproductive related tumors |
Hormones + Hormone Antagonist | may be palliative rather than curative |
Hormones + Hormone Antagonist | Tamoxifen |
Biologic Response Modifiers | Mitotane (Lysodren) |
Synthetic Erythropoietin | Epoetin alfa (Epogen, Procrit) |
Colony-Stimulating Factors | shortens length o time pt's are susceptible to life-threatening infection |
Colony-Stimulating Factors | Filgrastim (Granix, Neupogen) Sargamostim (Leukine) |
NADIR | reached lowest neutropenic state |
Platelet Enhancers | Oprelvekin (Neumega) |
Platelet Enhancers | Stimulate activity of megakaryocytes + thrombopoietin |
Acute Anemia | vascular volume loss, possible hypovolemia, normal red cell size and color |
Chronic Anemia | blood volume not affected, iron deficiency, RBC has low HGB, small and pale people |
Hemolytic Anemia | premature destruction of RBC, iron retention, increase in erythropoesis |
Thalassemia | defect in polypeptide chain synthesis, Hgb can't attach O2 to it; |
Thalassemia | Heinz Bodies (impair DNA synthesis + cause damage to RBC membrane) |
Schilling test | give B12 then do urine test to see if they have absorbed it |
Anti-anemic | Cyanocobalamin (Nascobal) |
Anti-anemic | Folic Acid (Folvite) |
Anti-anemic | Ferrous Sulfate (Feosol) |
Aplastic Anemia | damaged or destroyed stem cells; fatty replacement of bone marrow |
Aplastic Anemia | unusual relationship with CHF |