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Pathopharm II
Anemia + oncology
| Term | Definition |
|---|---|
| Alkylating Agents treat: | broad-spectrum; Hodginks, lymphoma myloma, breast cancer, ovarian cancer |
| Alkylating Agent | Cyclophsphamide (Cytoxan) |
| Antimetabolites treat: | choriocarcinoma, sarcoma, leukemia, head, neck, breast, and lung |
| Antimetabolite | Methotrexate (Rheumatrex, Trexall) |
| Antimetabolite | avoid > 6 months after use |
| Antimetabolite types | folic acid analog, purine analog, pyrimidine analogs |
| Antitumor Antibiotic treat: | solid tumors of lung, breast, ovary, bladder, leukemia, and lymphoma |
| Antitumor Antibiotic | CARDIOTOXIC |
| Antitumor Antibiotic | Doxorubicin (Adriamycin) "Red Devil" |
| Natural products/Miotic Inhibitors treat: | Hodkins, Non-hodkins lymphoma, leukemia, Kuposis sarcoma, Wilms tumor, bladder, breast |
| Natural products/Miotic Inhibitors | NERVOUS SYSTEM TOXICITY (crosses blood brain barrier) |
| Natural products/Miotic Inhibitors | Vincristine (Oncovin) |
| Hormones + Hormone Antagonist treat: | slow growth of reproductive related tumors |
| Hormones + Hormone Antagonist | may be palliative rather than curative |
| Hormones + Hormone Antagonist | Tamoxifen |
| Biologic Response Modifiers | Mitotane (Lysodren) |
| Synthetic Erythropoietin | Epoetin alfa (Epogen, Procrit) |
| Colony-Stimulating Factors | shortens length o time pt's are susceptible to life-threatening infection |
| Colony-Stimulating Factors | Filgrastim (Granix, Neupogen) Sargamostim (Leukine) |
| NADIR | reached lowest neutropenic state |
| Platelet Enhancers | Oprelvekin (Neumega) |
| Platelet Enhancers | Stimulate activity of megakaryocytes + thrombopoietin |
| Acute Anemia | vascular volume loss, possible hypovolemia, normal red cell size and color |
| Chronic Anemia | blood volume not affected, iron deficiency, RBC has low HGB, small and pale people |
| Hemolytic Anemia | premature destruction of RBC, iron retention, increase in erythropoesis |
| Thalassemia | defect in polypeptide chain synthesis, Hgb can't attach O2 to it; |
| Thalassemia | Heinz Bodies (impair DNA synthesis + cause damage to RBC membrane) |
| Schilling test | give B12 then do urine test to see if they have absorbed it |
| Anti-anemic | Cyanocobalamin (Nascobal) |
| Anti-anemic | Folic Acid (Folvite) |
| Anti-anemic | Ferrous Sulfate (Feosol) |
| Aplastic Anemia | damaged or destroyed stem cells; fatty replacement of bone marrow |
| Aplastic Anemia | unusual relationship with CHF |
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10154239976016049
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