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Pathopharm II

Anemia + oncology

Alkylating Agents treat: broad-spectrum; Hodginks, lymphoma myloma, breast cancer, ovarian cancer
Alkylating Agent Cyclophsphamide (Cytoxan)
Antimetabolites treat: choriocarcinoma, sarcoma, leukemia, head, neck, breast, and lung
Antimetabolite Methotrexate (Rheumatrex, Trexall)
Antimetabolite avoid > 6 months after use
Antimetabolite types folic acid analog, purine analog, pyrimidine analogs
Antitumor Antibiotic treat: solid tumors of lung, breast, ovary, bladder, leukemia, and lymphoma
Antitumor Antibiotic CARDIOTOXIC
Antitumor Antibiotic Doxorubicin (Adriamycin) "Red Devil"
Natural products/Miotic Inhibitors treat: Hodkins, Non-hodkins lymphoma, leukemia, Kuposis sarcoma, Wilms tumor, bladder, breast
Natural products/Miotic Inhibitors NERVOUS SYSTEM TOXICITY (crosses blood brain barrier)
Natural products/Miotic Inhibitors Vincristine (Oncovin)
Hormones + Hormone Antagonist treat: slow growth of reproductive related tumors
Hormones + Hormone Antagonist may be palliative rather than curative
Hormones + Hormone Antagonist Tamoxifen
Biologic Response Modifiers Mitotane (Lysodren)
Synthetic Erythropoietin Epoetin alfa (Epogen, Procrit)
Colony-Stimulating Factors shortens length o time pt's are susceptible to life-threatening infection
Colony-Stimulating Factors Filgrastim (Granix, Neupogen) Sargamostim (Leukine)
NADIR reached lowest neutropenic state
Platelet Enhancers Oprelvekin (Neumega)
Platelet Enhancers Stimulate activity of megakaryocytes + thrombopoietin
Acute Anemia vascular volume loss, possible hypovolemia, normal red cell size and color
Chronic Anemia blood volume not affected, iron deficiency, RBC has low HGB, small and pale people
Hemolytic Anemia premature destruction of RBC, iron retention, increase in erythropoesis
Thalassemia defect in polypeptide chain synthesis, Hgb can't attach O2 to it;
Thalassemia Heinz Bodies (impair DNA synthesis + cause damage to RBC membrane)
Schilling test give B12 then do urine test to see if they have absorbed it
Anti-anemic Cyanocobalamin (Nascobal)
Anti-anemic Folic Acid (Folvite)
Anti-anemic Ferrous Sulfate (Feosol)
Aplastic Anemia damaged or destroyed stem cells; fatty replacement of bone marrow
Aplastic Anemia unusual relationship with CHF