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Drug interactions
| Question | Answer | |
|---|---|---|
| Permisive | Presence of sub A is required for the full effects of sub B | Example: Cortisol and catecholamine responsiveness |
| Synergistic | Effect of sub A and B together is greater than the sum of their individual effects | Clopidogrel with aspirin |
| tachyphylactic | Acute to decrease in response to a drug after initial/ repeated administration | Nitrates, niacin, phenylephrine, LSD, MDMA |
| Additive | Effect of the sub A and B together is equal to sum of their individual effects | Example: Aspirin and Acetaminophen |