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Toxicities

Toxicities and side effects

QuestionAnswer
Acetaminophen Tx: N-acetylcysteine(replenishes glutathione)
AChE inhibitors, organophosphates Tx: Atropine>pralidoxime
Antimuscarinic, anticholinergic agents Tx: Physostigmine, control hyperthermia
Arsenic Dimercaprol, succiner
Benzodiazepines Flumazenil
Beta-blockers Atropine, glucagon
CO 100%O2, hyperbaric O2
Copper Penicillamine, Trientine
Cyanide Nitrite + thiosulfate, hydroxocobalamin
Digitalis (digoxin) Anti-dig Fab fragments
Heparin Protamine sulfate
Iron Deferoxamine, deferasirox, deferiprone
Lead EDTA, dimercaprol, succimer, penicillamine
Mercury Dimercaprol, succimer
Methanol, ethylene glycol Fomepizole> ethanol, dialysis
Methemoglobin Methylene blue, vitamin C
Opiods Naloxone
Salicylates NaHCO3, dialysis
TCAs NaHCO3
Warfarin Vitamin K(delayed), fresh frozen plasma (immediate)
Beers criteria Used to reduce inappropiate prescribing and harmful polypharmacy in geriatric population. Examples: Anticholinergics, antihistamines, antidepressants, BZD, opiods( increase risk of delirium, sedation, fall, constipation, urinary retention)
Beers criteria (continuation) alpha blockers (increase risk of hypotension) PPIs(increase risk of C difficile infection) NSAIDs(increase risk of GI bleeding, especially with concomitant anticoagulation)
Created by: Cdmac91