click below
click below
Normal Size Small Size show me how
Toxicities
Toxicities and side effects
Question | Answer |
---|---|
Acetaminophen | Tx: N-acetylcysteine(replenishes glutathione) |
AChE inhibitors, organophosphates | Tx: Atropine>pralidoxime |
Antimuscarinic, anticholinergic agents | Tx: Physostigmine, control hyperthermia |
Arsenic | Dimercaprol, succiner |
Benzodiazepines | Flumazenil |
Beta-blockers | Atropine, glucagon |
CO | 100%O2, hyperbaric O2 |
Copper | Penicillamine, Trientine |
Cyanide | Nitrite + thiosulfate, hydroxocobalamin |
Digitalis (digoxin) | Anti-dig Fab fragments |
Heparin | Protamine sulfate |
Iron | Deferoxamine, deferasirox, deferiprone |
Lead | EDTA, dimercaprol, succimer, penicillamine |
Mercury | Dimercaprol, succimer |
Methanol, ethylene glycol | Fomepizole> ethanol, dialysis |
Methemoglobin | Methylene blue, vitamin C |
Opiods | Naloxone |
Salicylates | NaHCO3, dialysis |
TCAs | NaHCO3 |
Warfarin | Vitamin K(delayed), fresh frozen plasma (immediate) |
Beers criteria | Used to reduce inappropiate prescribing and harmful polypharmacy in geriatric population. Examples: Anticholinergics, antihistamines, antidepressants, BZD, opiods( increase risk of delirium, sedation, fall, constipation, urinary retention) |
Beers criteria (continuation) | alpha blockers (increase risk of hypotension) PPIs(increase risk of C difficile infection) NSAIDs(increase risk of GI bleeding, especially with concomitant anticoagulation) |