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Beta blockers

selective and nonselective beta blockers

Acebutolol, atenolol, betaxolol, bisoprolol, esmolol, metoprolol Selective Beta 1 antagonists Acebutolol---partial agonist
Nadolol, pindolol, propanolol, timolol Nonselective antagonists(Beta-1= Beta-2) Pindolol--partial agonist
Carvedilol, lebetalol nonselective alpha and beta antagonists
beta blockers applications Angina pectoris- decrease HR and contractility--decrease O2 consumption MI---decrease mortality HT---decrease CO, renin secretion HF---decrease mortality(bisoprolol, carvedilol, metroprolol); Glaucoma---decrease the prod of aqueous humor(timolol)
Beta blockers applications ( continuation) variceal bleeding---decrease hepatic venous pressure gradient and portal HT (nadolol, propanolol)
Beta blockers Side effects Erectile dysfunction, CV adverse effects (bradycardia, AV block, HF) CNS effects (seizures, sedation, sleep alteretions) ; dyslipidemia (metoprolol);asthma/COPD exacerbations ***use with caution in cocaine users*****
Created by: Cdmac91



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