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Beta blockers
selective and nonselective beta blockers
| Question | Answer |
|---|---|
| Acebutolol, atenolol, betaxolol, bisoprolol, esmolol, metoprolol | Selective Beta 1 antagonists Acebutolol---partial agonist |
| Nadolol, pindolol, propanolol, timolol | Nonselective antagonists(Beta-1= Beta-2) Pindolol--partial agonist |
| Carvedilol, lebetalol | nonselective alpha and beta antagonists |
| beta blockers applications | Angina pectoris- decrease HR and contractility--decrease O2 consumption MI---decrease mortality HT---decrease CO, renin secretion HF---decrease mortality(bisoprolol, carvedilol, metroprolol); Glaucoma---decrease the prod of aqueous humor(timolol) |
| Beta blockers applications ( continuation) | variceal bleeding---decrease hepatic venous pressure gradient and portal HT (nadolol, propanolol) |
| Beta blockers Side effects | Erectile dysfunction, CV adverse effects (bradycardia, AV block, HF) CNS effects (seizures, sedation, sleep alteretions) ; dyslipidemia (metoprolol);asthma/COPD exacerbations ***use with caution in cocaine users***** |