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Direct, indirect sympathomimetics

salmeterol Direct sympathomimetics action: Beta-2 >Beta-1 Long term tx for asthma or COPD
Dobutamine Direct sympathomimetics Beta-1> Beta-2, alpa receptor HF, (inotropic>chronotropic) Cardiac stress testing
Dopamine Direct sympathomimetics D1=D2> Beta> alpha Unstable bradycardia HF shock Inotropic and chronotropic effects at low dose due to Beta effects Vasoconstriction at high doses due to alpha effects
Epinephrine Direct sympathomimetics Beta> alpha action Stonger effect at Beta 2 receptor than NE Anaphylaxis asthma Open angle glaucoma(alpha effects predominate at high doses)
Fenoldopam Direct sympathomimetics D1 Postoperative HT, Hypertensive crisis, vasodilator(coronary, peripheral, renal and splachnic) Promotes natriuresis S.E: Hypotension, Tachycardia
Isoproterenol Direct sympathomimetics action: Beta-2 = Beta-1 Electrophysiologic evaluation of Tachyarrhythmias S.E: can worse ischemia
Midodrine Direct sympathomimetics action: alpha 1 Autonomic insufficiency and postural hypotension S.E: may exacerbate supine HT
Mirabegron Direct sympathomimetics action: Beta-3 Urinary urge incontinence or overactive bladder
NE Direct sympathomimetics action:alpha-1> alpha-2>Beta-1 Hypotension, septic shock
Phenylephrine Direct sympathomimetics action: alpha1>alpha-2 Hypotension (vasoconstrictor) ocular procedures(mydriatic) Rhinitis(descongestant)
Amphetamine Indirect general agonist re-uptake inhibitor Release stored catecholamines Uses: Narcolepsy, obesity, ADHD
Cocaine Indirect general agonist Re-uptake inhibitor vasoconstriction and local anesthesia Never give Beta blockers--> unopposed alpha-1 activation Extreme HT
Ephedrine Indirect general agonist, release stored catecholamines Nasal decongestion Urinary incontinence Hypotension
albuterol Direct sympathomimetics action: Beta-2 >Beta-1 acute asthma, COPD
Created by: Cdmac91



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