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sympathomimetics
Direct, indirect sympathomimetics
Question | Answer | |
---|---|---|
salmeterol | Direct sympathomimetics action: Beta-2 >Beta-1 | Long term tx for asthma or COPD |
Dobutamine | Direct sympathomimetics Beta-1> Beta-2, alpa receptor | HF, (inotropic>chronotropic) Cardiac stress testing |
Dopamine | Direct sympathomimetics D1=D2> Beta> alpha | Unstable bradycardia HF shock Inotropic and chronotropic effects at low dose due to Beta effects Vasoconstriction at high doses due to alpha effects |
Epinephrine | Direct sympathomimetics Beta> alpha action Stonger effect at Beta 2 receptor than NE | Anaphylaxis asthma Open angle glaucoma(alpha effects predominate at high doses) |
Fenoldopam | Direct sympathomimetics D1 | Postoperative HT, Hypertensive crisis, vasodilator(coronary, peripheral, renal and splachnic) Promotes natriuresis S.E: Hypotension, Tachycardia |
Isoproterenol | Direct sympathomimetics action: Beta-2 = Beta-1 | Electrophysiologic evaluation of Tachyarrhythmias S.E: can worse ischemia |
Midodrine | Direct sympathomimetics action: alpha 1 | Autonomic insufficiency and postural hypotension S.E: may exacerbate supine HT |
Mirabegron | Direct sympathomimetics action: Beta-3 | Urinary urge incontinence or overactive bladder |
NE | Direct sympathomimetics action:alpha-1> alpha-2>Beta-1 | Hypotension, septic shock |
Phenylephrine | Direct sympathomimetics action: alpha1>alpha-2 | Hypotension (vasoconstrictor) ocular procedures(mydriatic) Rhinitis(descongestant) |
Amphetamine | Indirect general agonist re-uptake inhibitor Release stored catecholamines | Uses: Narcolepsy, obesity, ADHD |
Cocaine | Indirect general agonist Re-uptake inhibitor | vasoconstriction and local anesthesia Never give Beta blockers--> unopposed alpha-1 activation Extreme HT |
Ephedrine | Indirect general agonist, release stored catecholamines | Nasal decongestion Urinary incontinence Hypotension |
albuterol | Direct sympathomimetics action: Beta-2 >Beta-1 | acute asthma, COPD |