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General pharm

G-protein linked second messengers

alpha-1 receptor Gq increase vascular s. muscle contraction, increase pupillary dilator m. contraction (mydriasis), increase intestinal and bladder sphincter m. contraction
alpha 2 receptor Gi decrease sympathetic outflow, decrease insulin release, decrease lipolysis, increase platelet aggregation, decrease aqueous humor production
Beta 1 receptor increase HR, contractility, renin release, lipolysis Gs
Beta 2 receptor Gs Vasodilation, bronchodilation, increase lipolysis, increase insulin release, decrease uterine tone , ciliary m relaxation, increase aqueous humor prod.
Beta 3 receptor Gs increase lipolysis, increase thermogenesis in s. muscle
M1 receptor Gq CNS, enteric nervous system
M2 receptor Gi decrease HR and contractility of the atria
M3 receptor Gq increase exocrine gland secretions, increase gut peristalsis, increase bladder contraction, bronchoconstriction, increase pupillary sphincter m. contraction (miosis), ciliary m contraction (accommodiation)
D1 receptor Gs relaxes renal vascular s. muscle, activates direct pathway of striatum
D2 receptor Gi Modulates transmitter release in the brain, inhibits indirect pathway of striatum
H1 receptor Gq increase nasal adn bronchial mucus prod., increase vascular permeability, contraction of bronchioles, pruritus, pain
H2 receptor Gs increase gastric acid secretion
V1 receptor Gq increase vascular smooth m. contraction
V2 receptor Gs increase H2O permeability and reabsorption in collecting tubules of kidney
Gq Activation of phospholipase C In lipids, phospholipase C breaks PIP2--> DAG and IP3 DAG--->Protein Kinase C IP3--> increase intracellular Ca2+ concentration---> smooth m. contraction
Gs activation of adenylate cyclase--> ATP converted to cAMP cAMP activates protein kinase A--->increase intracellular Ca2+ concentration in heart
Gi Inhibits adenylate cyclase decrease cAMP--->no cAMP dependent protein kinase ---> inhibition myosin light chain kinase (smooth m.)
Created by: Cdmac91