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RBC forms/anemia

QuestionAnswer
Spherocytes Hereditary spherocytosis, autoimmune hemolysis
Elliptocyte hereditary elliptocytosis
Macro-ovalocyte Marrow failure, Megablastic anemia (hypersegmented polys common),
Helmet cell/schistocyte DIC, TTP/HUS, traumatic hemolysis
Sickle cell Sickle cell anemia
Acanthyocyte (spur cell) Spiny appearance in liver disease and abetalipoproteinemia
Target cell HbC disease, Asplenia, Liver disease, Thalassemia
Burr cell TTP/HUS
Basophilic stippling Thalassemia, Anemia of chronic disease, Iron deficiency, lead poisoning
HALT Pneumonic for taret cells (Hbc disease, asplenia, liver disease, thalassemia)
Tail Basophilic stippling (Thalassemia, anemia of chronic disease, iron deficiency, lead poisoning)
Heinz bodies formation Oxidation of iron from ferrous to ferric form leads to denature hemoglboin preciptiation and damage to RBC membrane (bite cells)
Howell Jolly bodies formation Basophilic nuclear remnants found in RBC
Howel jolly bodies Hyposplenia, asplenia
Heinz bodies alpha thalassemia, G6PD deficiency
Microcytic anemias Iron deficiency, Thalassemia, Lead poisoning, sideroblastic anemia
Macrocytic Megaloblastic (B12/folate), drugs that block DNA (sulfa, phenytoidn AZT)
Normocytic hemorrhage, enzyme defects, RBC defects (hereditary), bone marrow disorders, hemaglobinopathies (sickel cell), auotimmune hemolytic, Anemia of chronic disease
Iron deficiency = serum iron, TIBC, ferritin levels decreased serum iron, increased TIBC, decreased ferritin
Anemia of chronic disease= TIBC, ferritin Decreased TIBC, increased ferritin,
Pneumonic for microcytic anemia LIST (lead poisoning, iron deficiency, sideroblastic anemia, thalassemia)
Created by: ddecampo