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RBC forms/anemia
Question | Answer |
---|---|
Spherocytes | Hereditary spherocytosis, autoimmune hemolysis |
Elliptocyte | hereditary elliptocytosis |
Macro-ovalocyte | Marrow failure, Megablastic anemia (hypersegmented polys common), |
Helmet cell/schistocyte | DIC, TTP/HUS, traumatic hemolysis |
Sickle cell | Sickle cell anemia |
Acanthyocyte (spur cell) | Spiny appearance in liver disease and abetalipoproteinemia |
Target cell | HbC disease, Asplenia, Liver disease, Thalassemia |
Burr cell | TTP/HUS |
Basophilic stippling | Thalassemia, Anemia of chronic disease, Iron deficiency, lead poisoning |
HALT | Pneumonic for taret cells (Hbc disease, asplenia, liver disease, thalassemia) |
Tail | Basophilic stippling (Thalassemia, anemia of chronic disease, iron deficiency, lead poisoning) |
Heinz bodies formation | Oxidation of iron from ferrous to ferric form leads to denature hemoglboin preciptiation and damage to RBC membrane (bite cells) |
Howell Jolly bodies formation | Basophilic nuclear remnants found in RBC |
Howel jolly bodies | Hyposplenia, asplenia |
Heinz bodies | alpha thalassemia, G6PD deficiency |
Microcytic anemias | Iron deficiency, Thalassemia, Lead poisoning, sideroblastic anemia |
Macrocytic | Megaloblastic (B12/folate), drugs that block DNA (sulfa, phenytoidn AZT) |
Normocytic | hemorrhage, enzyme defects, RBC defects (hereditary), bone marrow disorders, hemaglobinopathies (sickel cell), auotimmune hemolytic, Anemia of chronic disease |
Iron deficiency = serum iron, TIBC, ferritin levels | decreased serum iron, increased TIBC, decreased ferritin |
Anemia of chronic disease= TIBC, ferritin | Decreased TIBC, increased ferritin, |
Pneumonic for microcytic anemia | LIST (lead poisoning, iron deficiency, sideroblastic anemia, thalassemia) |