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HIV genome Diploid
env gene Gp160 glycosylated and cleaved within ER and Golgi in gp 120(attachment to host CD4+ T cell) and gp41(fusion and entry)
Gag gene P24 --- capsid P17--- matrix proteins
Pol gene Reverse transcriptase-- synthesizes dsDNA from RNA--dsDNA intregrates into host genome aspartate protease, integrease Mutations in this gene are responsible to resistant HAART tx.
CCR5 Coreceptor --- on macrophages (Early infection) Homozygous CCR5 mutation--- immunity Heterozygous ". "------slower course
CXCR4 On T cells--late infection
Four stages of untx infection Flu like (acute) Feeling fine (latent) Falling count Final crisis
Created by: Cdmac91