CAG expansion, AD disease, huntingtin gene undergoes deacetylation of histones--> this prevents the transcrition of certain genes that code for neurotrophic factors--> neuronal cell death.

CGG expansion, FMR1 gene-- hypermethylation--> â¬ï¸ expansion, X-linked dominant

GAA expansion, AR, frataxin protein(iron binding protein)

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3 expansion-genetics

Question	Answer
Huntington dx	CAG expansion, AD disease, huntingtin gene undergoes deacetylation of histones--> this prevents the transcrition of certain genes that code for neurotrophic factors--> neuronal cell death.
Myotonic dystrophy	CTG, DMPK gene, AD
Fragile X	CGG expansion, FMR1 gene-- hypermethylation--> â¬ï¸ expansion, X-linked dominant
Friedreich ataxia	GAA expansion, AR, frataxin protein(iron binding protein)