click below
click below
Normal Size Small Size show me how
3 expansion-genetics
Question | Answer |
---|---|
Huntington dx | CAG expansion, AD disease, huntingtin gene undergoes deacetylation of histones--> this prevents the transcrition of certain genes that code for neurotrophic factors--> neuronal cell death. |
Myotonic dystrophy | CTG, DMPK gene, AD |
Fragile X | CGG expansion, FMR1 gene-- hypermethylation--> â¬ï¸ expansion, X-linked dominant |
Friedreich ataxia | GAA expansion, AR, frataxin protein(iron binding protein) |