Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Don't know
remaining cards
To flip the current card, click it or press the Spacebar key.  To move the current card to one of the three colored boxes, click on the box.  You may also press the UP ARROW key to move the card to the "Know" box, the DOWN ARROW key to move the card to the "Don't know" box, or the RIGHT ARROW key to move the card to the Remaining box.  You may also click on the card displayed in any of the three boxes to bring that card back to the center.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

TSG Path

Tumor suppressor-definition Loss of function-- increase cancer risk---two alleles of a TSG must be lost for expression of disease.
APC Negative regulator of beta catenin/ WNT pathway. Related to colorectal cancer (assoc with FAP)
BRCA1/BRCA2 DNA repair protein---- breast, ovarian, and pancreatic cancer
CDKN2A p16, blocks G1---S phase......related melanoma, pAncreatic cancer
DCC Deleted Colon Cancer----Colon cancer
DPC4/SMAD4 Deleted Pancreatic cancer----pancreatic cancer
MEN1 Menin---MEN1
NF1 Neurofibromin (RAS GTPase activating protein) Neurofibromatosis type 1
nF2 Merlin(schwannomin) protein--- Neurofibromatosis type 2
PTEN Tyrosine phosphatase of PIP3(protein kinase, B (akt) activation)-----Breast cancer, prostate cancer, endometrial cancer
Rb Inhibits E2F; blocks G1-- S phase.....retinoblastoma, osteosarcoma
TP53 P53, activates p21, blocks G1--S phase most human cancers, Li- fraumeni syndrome; SBLA cancer syndrome: Sarcoma, Breast, Leukemia, Adrenal gland
TSC1 Harmatin protein---- tuberous sclerosis
TSC2 Tuberin protein--- Tubeorus slcerosis
VHL Inhibits hypoxia inducible factor 1a----- von Hippel Lindau dx
WT1 Transcription factor that regulates urogenital development----Wilms tumor (nephroblastoma)
Created by: Cdmac91