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Oncogen-GOF
Question | Answer |
---|---|
Alk | Receptor tyrosine kinase- lung adenocarcinoma |
BCR-ABL | Tyrosine kinase- CML, ALL |
BCL-2 | Antiapoptotic- follicular and large B cell lymphoma |
BRAF | Serine/ threonine kinase-- melanoma,N-HL, papillary thyroid carcinoma |
C-kit | Cytokine receptor--- gastrointestinal stromal tumor (GIST) |
c-MYC | Transcription factor--Burkitt lymphoma |
HER/neu | Receptor tyrosine kinase--- Breast and gastric carcinomas |
JAK2 | Tyrosine kinase- chronic myeloproliferative disorders |
KRAS | GTPase--- colon cancer, lung cancer, pancreatic cancer |
MYCL-1 | Transcription factor- lung tumor |
MYCN | Transcription factor- Neuroblastoma |
RET | Receptor tyrosine kinase-- MEN 2A, 2B, medullary thyroid carcinoma |