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Oncogen-GOF

QuestionAnswer
Alk Receptor tyrosine kinase- lung adenocarcinoma
BCR-ABL Tyrosine kinase- CML, ALL
BCL-2 Antiapoptotic- follicular and large B cell lymphoma
BRAF Serine/ threonine kinase-- melanoma,N-HL, papillary thyroid carcinoma
C-kit Cytokine receptor--- gastrointestinal stromal tumor (GIST)
c-MYC Transcription factor--Burkitt lymphoma
HER/neu Receptor tyrosine kinase--- Breast and gastric carcinomas
JAK2 Tyrosine kinase- chronic myeloproliferative disorders
KRAS GTPase--- colon cancer, lung cancer, pancreatic cancer
MYCL-1 Transcription factor- lung tumor
MYCN Transcription factor- Neuroblastoma
RET Receptor tyrosine kinase-- MEN 2A, 2B, medullary thyroid carcinoma
Created by: Cdmac91