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GENERIC NAME Ondansetron
Ondansetron BRAND NAME Zofran
Ondansetron CLASS Antiemetic agent
Ondansetron MECHANISM OF ACTION Selectively blocks serotonin 5-HT3 receptors located in the CNS at the chemoreceptor trigger zone and in the peripheral nervous system on nerve-terminals of the vagus nerve
Ondansetron CONTRAINDICATIONS Hypersensitivity,Use with caution in patients with hepatic impairment
Ondansetron ADVERSE REACTIONS CNS; Headache, malaise, fatigue, dizziness, fever, sedation, extrapyramidal syndrome, Cardiovascular; Chest pain, arrhythmias Respiratory; Hypoxia, GI & Hepatic; Diarrhea, constipation, abdominal pain, xerostomia, decreased appetite, Skin; Rash
Ondansetron INCOMPATABILITIES/DRUG INTERACTIONS Inducers or inhibitors of P450 drug metabolizing enzymes may alter the clearance of Ondansetron. No dosage adjustment is recommended.
Ondansetron DOSE/ROUTE, Adult Dosage 4 – 8 mg IV slow push over 2 – 5 minutes 8 mg PO ODT or tablet
Ondansetron Pediatric Dosage (1 month to 12 years old) Greater than 40 kg- 4 mg IV slow push over 2 – 5 minutes; Less than 40 kg- 0.1 mg/kg IV slow push over 2 – 5 minutes; 4-12 years old 4 mg PO ODT or ODT
Ondansetron ONSET OF ACTION Unknown but maybe 10-30 minutes
Ondansetron PEAK EFFECTS unknown
Ondansetron DURATION OF ACTION Half life ~ 4 hours. Duration unknown
Created by: klindley