click below
click below
Normal Size Small Size show me how
GHY3
Hi Yield goljan pt3
Question | Answer |
---|---|
Tumor acute inflammation | swelling; ↑ vessel permeability (histamine) |
Dolor acute inflammation | pain; bradykinin, PGE |
Acute inflammation | neutrophil dominant; ↑ IgM |
Initial vessel events | transient vasoconstriction → arteriolar vasodilation → ↑ venular permeability |
Neutrophil rolling acute inflammation | due to selectins |
Integrins | neutrophil adhesion molecules; C5a and leukotriene B, activate; neutrophil margination |
CD11/CD18 | markers for integrins |
Endothelial cell adhesion molecules | activated by IL-1 and TNF |
ICAM | intercellular adhesion molecule |
VCAM | vascular cell adhesion molecule Leukocyte adhesion molecule defect |
Activation neutrophil adhesion molecules | neutrophilic leukocytosis; corticosteroids |
Activation neutrophil adhesion molecules | neutropenia; endotoxins |
Chemotaxis | directed movement; C5a and LTB4 |
Opsonizing agents | IgG, C3b; enhance phagocytosis |
Neutrophils, monocytes, macrophages | receptors for IgG, C3b |
O2-dependent MPO system | most potent microbicidal system; neutrophils, monocytes |
ProductionofsuperoxidefromO2 | NADPH oxidase with NADPH cofactor; produces respiratory burst |
Nitro blue tetrazolium (NBT) | test for respiratory burst |
Superoxide dismutase | converts superoxide to peroxide |
Myeloperoxidase | lysosomal enzyme that combines peroxide + Cl to form bleach (HOCl) |
Microbicidal defects | chronic granulomatous disease childhood (XR), myeloperoxidase deficiency (AR) |
Chronic granulomatous disease | absent NADPH oxidase; no respiratory burst |
Chronic granulomatous disease | Staphylococcus aureus not killed (catalase positive) |
Chronic granulomatous disease | Streptococcus killed (catalase negative) |
Myeloperoxidase deficiency | AR; respiratory burst present; no bleach produced |
Opsonization defect | Bruton’s agammaglobulinemia (XR, decreased IgG) |
Phagocytosis defect | Chediak-Higashi (see cell injury); also has defect in microtubule polymerization |
COX inhibitors | non-steroidals (non-selective), selective COX-2 inhibitors |
PGE2 | vasodilation, fever |
PGI2 | vasodilator; prevent platelet aggregation |
Nitric oxide | vasodilator; FR gas from conversion arginine to citrulline |
IL-1 and TNF | fever, synthesis acute phase reactants in liver, leukocytosis |
IL-6 | stimulated by IL-1; stimulates synthesis of acute phase reactants |
Acute phase reactants | fibrinogen, ferritin, C-reactive protein |
Bradykinin | kinin produced in conversion of factor XII to factor XI |
Bradykinin | pain, vasodilator, vessel permeability; cough/angioedema, ACE inhibitors |
Anaphylatoxins | C3a and C5a; directly stimulate mast cell release of histamine |
Prostaglandin I2 | synthesized by endothelial cells; vasodilator, inhibits platelet aggregation |
Lipoxygenase | hydroxylation of arachidonic acid |
Zileuton | inhibits lipoxygenase |
Zafirlukast, montelukast | block lipoxygenase receptor |
LTC4, -D4, -E4 | bronchoconstrictors |
TXA2 | synthesized by platelets; platelet aggregation, vasoconstriction, bronchoconstriction |
Dipyridamole | inhibits thromboxane synthase |
Corticosteroids | inhibits phospholipase A2, activation neutrophil adhesion molecules |
Corticosteroids | neutrophilic leukocytosis, lymphopenia, eosinopenia |
Fever | right shift OBC; hostile to bacterial/viral replication |
Chronic inflammation | monocyte/macrophage; ↑ IgG; repair by fibrosis |
Granuloma | cellular immunity; macrophages interact with TH1 class cells (memory cells) |
Positive PPD | Langerhan’s cells process PPD and interact with TH1 class cells |