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Hi Yield goljan pt3

Tumor acute inflammation swelling; ↑ vessel permeability (histamine)
Dolor acute inflammation pain; bradykinin, PGE
Acute inflammation neutrophil dominant; ↑ IgM
Initial vessel events transient vasoconstriction → arteriolar vasodilation → ↑ venular permeability
Neutrophil rolling acute inflammation due to selectins
Integrins neutrophil adhesion molecules; C5a and leukotriene B, activate; neutrophil margination
CD11/CD18 markers for integrins
Endothelial cell adhesion molecules activated by IL-1 and TNF
ICAM intercellular adhesion molecule
VCAM vascular cell adhesion molecule Leukocyte adhesion molecule defect
Activation neutrophil adhesion molecules neutrophilic leukocytosis; corticosteroids
Activation neutrophil adhesion molecules neutropenia; endotoxins
Chemotaxis directed movement; C5a and LTB4
Opsonizing agents IgG, C3b; enhance phagocytosis
Neutrophils, monocytes, macrophages receptors for IgG, C3b
O2-dependent MPO system most potent microbicidal system; neutrophils, monocytes
ProductionofsuperoxidefromO2 NADPH oxidase with NADPH cofactor; produces respiratory burst
Nitro blue tetrazolium (NBT) test for respiratory burst
Superoxide dismutase converts superoxide to peroxide
Myeloperoxidase lysosomal enzyme that combines peroxide + Cl to form bleach (HOCl)
Microbicidal defects chronic granulomatous disease childhood (XR), myeloperoxidase deficiency (AR)
Chronic granulomatous disease absent NADPH oxidase; no respiratory burst
Chronic granulomatous disease Staphylococcus aureus not killed (catalase positive)
Chronic granulomatous disease Streptococcus killed (catalase negative)
Myeloperoxidase deficiency AR; respiratory burst present; no bleach produced
Opsonization defect Bruton’s agammaglobulinemia (XR, decreased IgG)
Phagocytosis defect Chediak-Higashi (see cell injury); also has defect in microtubule polymerization
COX inhibitors non-steroidals (non-selective), selective COX-2 inhibitors
PGE2 vasodilation, fever
PGI2 vasodilator; prevent platelet aggregation
Nitric oxide vasodilator; FR gas from conversion arginine to citrulline
IL-1 and TNF fever, synthesis acute phase reactants in liver, leukocytosis
IL-6 stimulated by IL-1; stimulates synthesis of acute phase reactants
Acute phase reactants fibrinogen, ferritin, C-reactive protein
Bradykinin kinin produced in conversion of factor XII to factor XI
Bradykinin pain, vasodilator, vessel permeability; cough/angioedema, ACE inhibitors
Anaphylatoxins C3a and C5a; directly stimulate mast cell release of histamine
Prostaglandin I2 synthesized by endothelial cells; vasodilator, inhibits platelet aggregation
Lipoxygenase hydroxylation of arachidonic acid
Zileuton inhibits lipoxygenase
Zafirlukast, montelukast block lipoxygenase receptor
LTC4, -D4, -E4 bronchoconstrictors
TXA2 synthesized by platelets; platelet aggregation, vasoconstriction, bronchoconstriction
Dipyridamole inhibits thromboxane synthase
Corticosteroids inhibits phospholipase A2, activation neutrophil adhesion molecules
Corticosteroids neutrophilic leukocytosis, lymphopenia, eosinopenia
Fever right shift OBC; hostile to bacterial/viral replication
Chronic inflammation monocyte/macrophage; ↑ IgG; repair by fibrosis
Granuloma cellular immunity; macrophages interact with TH1 class cells (memory cells)
Positive PPD Langerhan’s cells process PPD and interact with TH1 class cells
Created by: mcafej02



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