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immuno/cancer drugs

Cyclsporine: Mechanism Blocks T cell differentiation by binding to cyclophilins and inhibiting calcineurin. Calcineurin helps to produce Il-2 and it's receptor.
Cyclosporine: clinical use Suppresses organ rejection after transplantation
Cyclsporine: toxicity Predisposes patients to viral infections, lymphoma; nephrotoxic (give mannitol diuresis)
Tacrolimus (aka __): mechanism FK506. Inhibits IL-2 and other cytokines. Binds to Fk-binding proteins
What are the two immunosuppresants that work by blocking IL-2 release? Cyclosporin, Tacrolimus
Azothioprine: mechanism antimetabolite precursor of 6 mercaptopurine that interferes with teh metabolism of nucleic acids. toxic to lymphocytes
Azothioprine: clinical use Kidney transplantation, autoimmune disorders (glomerulonephritis, hemolytic anemia)
Azothioprine: toxicity BM suppression. ACtive metabolite mercaptopurine is metabolized by xanthine oxidase (therefore toxic effects may be increased by allopurinol)
Muromonab-CD3 (aka ___): Mechanism OKT3. Blocks T cell-signaling. Monoclonal antibody that binds to CD3 (epsilon chain) on the surface of T cells. It blocks the cellular interaction with CD3 protein responsible for T-cell signal transduction.
Muronmonab-CD3: Toxicity Cytokine release syndrome, hypersensitivty reaction
Sirolimus (rapamycin): mechanism Inhibits T-cell proliferation in resposne to IL-2. Binds to mTOR.
Sirolimus (rapamycin): clinical use Immunosuppression after kidney transplantation in combination with cyclosporine and corticosteroids
Sirolimus (rapamycin): toxicity Hyperlipidemia, thrombocytopenia, leukopenia
Mycophenolate mofetil: Mechanism Inhibits de novo guanine synthesis and blocks lymphocyte production
Daclizumab: mechanism monoclonal antibody with high affinity for IL-2 receptor on activated T-cells
Aldesleukin (aka ___): clinical use interleukin-2, Renal cell carcinoma, metastatic melanoma
Erythopoietin (aka ___): clinical use (epoietin), anemias, especially after renal failure
Filgrastim (aka ___): clinical use (granulocyte-CSF). recovery of bone marrow
Sargramostin (aka ___): clinical use granulocyte-macrophage CSF). Recovery of bone marrow
alpha-interferon Hep B/C, Kaposi's sarcoma, leukemias, malignant melanoma
Beta interferon Multiple sclerosis
gamma interferon Chronic granulomatous disease
Oprelvekin (aka ___) interleukin 11 (thrombocytopenia)
Thrombopoietin Thrombocytopenia
Created by: ddecampo