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Immunology 1

Cytokines have 2 roles: ____, ____. Chemokines ____. Cytokines = regulate lymphocyte development, determine type of immune response, Chemokines= stimulate leukocyte movement
Drainage site: upper limb, breast Axillary
Drainage site: Stomach Celiac
Drainage site: Duodenum, jejunum Superior mesenteric
Drainage site: Sigmoid colon Colic --> inferior mesenteric
Drainage site: Rectum (lower par), anal canl above pectinate line Internal iliac
Drainage site: Anal canal below pectinate line Superficial inguinal
Drainage site: Testes Superficial and deep plexuses --> para-aortic
Drainage site: Scrotum Superficial inguinal
Drainage site: Thigh (superficial) Superifical inguinal
Drainage site: Lateral site of dorsume of foot Popliteal
right lymphatic duct drains: Right arm, and right half of head
Thoracic duct Drains everything else
IL-1 Secreted by macrophages. Causes acute inflammation (1 = alpha)A = acute inflammation (Increase pg), L = Leukocytosis = (activate with chemokines)F= fever, A = adhesion molecules are put on endothelial cells
IL-2 Secreted by Th cells. Stimulates growth of Th and CTL cells.
IBD is caused by ____ due to a deficiency in ___. IBD = T cell dysregulation following IL-2 deficiency
Drugs against IL-2. What are they called, function and uses Basiliximab, daclizumab (transplantation) anti-IL-2 monoclonal antibodies, Cylcosporine = T cell response blocker (decreases IL-2) = transplantation, rheumatoid arthritis
IL-3 Secreted by activated T cells. Supports the growth and differentiation of bone marrow stem cells, has a function similar to GM-CSF
IL-4 Secreted by Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG. (B means 2 in order = 4 Equals 2 in order) B cell + 2(Th2) = (IgEquals) IL4.
IL-5 Secreted by Th2 cells. Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates production of acute-phase reactants and eosinophils (Give the high-five for the person who got an AcE) = IgA, Eosinophil
IL-6 secreted by Th cells and macrophages. Stimulates production of acute phase reactants and immunoglobulins. (Sick with a fever at 6).
Fever is caused by 3 pyrogens: TNF-alpha, IL-1, IL-6
IL-8 (CXCL8) Secreted by macrophages. "What I 8 is Neutritious. (Attract neutrophils via chemotaxis)
IL-10 Secreted by regulatory T cells. inhibits activation of activated T cells.
IL-12 Secreted by B cells and macrophages. Activates natural killer cells and Th1 cells. (The 12V bulb on macrophage wants TELLs 1 helper (TH1) and 2 killers (CTL and NK) to produce IFN-gamma (1 + 2= gamma = 3 by order).
Decrease in IFN-gamma caues Increased infections by intracellular microbes such as listeria monocytogenes and mycobacteria
IFN gamma Secreted by Th1 cells. Stimulates macrophages. Mediates septic schok, causes leukocyte recruitment, vascular leak
Helper T cells CD4, TCR, CD3, CD28, CD40L
Cytotoxic T cells CD8, TCR, CD3
B cells IgM, B7, CD19, CD20, CD21, CD40, MHC II
Which Cell surface proteins is the receptor for EBV? CD21
Macrophages MHC II, B7, CD40, CD14, Receptors for Fc and C3b
NK Receptors for MHC1, CD16 (binds Fc of IgG), CD56,
All cells except RBC MHC1
Created by: ddecampo