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Immunology 1
| Question | Answer |
|---|---|
| Cytokines have 2 roles: ____, ____. Chemokines ____. | Cytokines = regulate lymphocyte development, determine type of immune response, Chemokines= stimulate leukocyte movement |
| Drainage site: upper limb, breast | Axillary |
| Drainage site: Stomach | Celiac |
| Drainage site: Duodenum, jejunum | Superior mesenteric |
| Drainage site: Sigmoid colon | Colic --> inferior mesenteric |
| Drainage site: Rectum (lower par), anal canl above pectinate line | Internal iliac |
| Drainage site: Anal canal below pectinate line | Superficial inguinal |
| Drainage site: Testes | Superficial and deep plexuses --> para-aortic |
| Drainage site: Scrotum | Superficial inguinal |
| Drainage site: Thigh (superficial) | Superifical inguinal |
| Drainage site: Lateral site of dorsume of foot | Popliteal |
| right lymphatic duct drains: | Right arm, and right half of head |
| Thoracic duct | Drains everything else |
| IL-1 | Secreted by macrophages. Causes acute inflammation (1 = alpha)A = acute inflammation (Increase pg), L = Leukocytosis = (activate with chemokines)F= fever, A = adhesion molecules are put on endothelial cells |
| IL-2 | Secreted by Th cells. Stimulates growth of Th and CTL cells. |
| IBD is caused by ____ due to a deficiency in ___. | IBD = T cell dysregulation following IL-2 deficiency |
| Drugs against IL-2. What are they called, function and uses | Basiliximab, daclizumab (transplantation) anti-IL-2 monoclonal antibodies, Cylcosporine = T cell response blocker (decreases IL-2) = transplantation, rheumatoid arthritis |
| IL-3 | Secreted by activated T cells. Supports the growth and differentiation of bone marrow stem cells, has a function similar to GM-CSF |
| IL-4 | Secreted by Th2 cells. Promotes growth of B cells. Enhances class switching to IgE and IgG. (B means 2 in order = 4 Equals 2 in order) B cell + 2(Th2) = (IgEquals) IL4. |
| IL-5 | Secreted by Th2 cells. Promotes differentiation of B cells. Enhances class switching to IgA. Stimulates production of acute-phase reactants and eosinophils (Give the high-five for the person who got an AcE) = IgA, Eosinophil |
| IL-6 | secreted by Th cells and macrophages. Stimulates production of acute phase reactants and immunoglobulins. (Sick with a fever at 6). |
| Fever is caused by 3 pyrogens: | TNF-alpha, IL-1, IL-6 |
| IL-8 (CXCL8) | Secreted by macrophages. "What I 8 is Neutritious. (Attract neutrophils via chemotaxis) |
| IL-10 | Secreted by regulatory T cells. inhibits activation of activated T cells. |
| IL-12 | Secreted by B cells and macrophages. Activates natural killer cells and Th1 cells. (The 12V bulb on macrophage wants TELLs 1 helper (TH1) and 2 killers (CTL and NK) to produce IFN-gamma (1 + 2= gamma = 3 by order). |
| Decrease in IFN-gamma caues | Increased infections by intracellular microbes such as listeria monocytogenes and mycobacteria |
| IFN gamma | Secreted by Th1 cells. Stimulates macrophages. Mediates septic schok, causes leukocyte recruitment, vascular leak |
| Helper T cells | CD4, TCR, CD3, CD28, CD40L |
| Cytotoxic T cells | CD8, TCR, CD3 |
| B cells | IgM, B7, CD19, CD20, CD21, CD40, MHC II |
| Which Cell surface proteins is the receptor for EBV? | CD21 |
| Macrophages | MHC II, B7, CD40, CD14, Receptors for Fc and C3b |
| NK | Receptors for MHC1, CD16 (binds Fc of IgG), CD56, |
| All cells except RBC | MHC1 |
Created by:
ddecampo
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