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Diabetes Drug

Lecture Notes

QuestionAnswer
Chlorpropamide (Diabinese) - 1st Gen SU = Increase insulin secretion
Glyburide (Diabeta, Glynase, Micronase)- 2nd Gen SU = Increase insulin secretion
Glipzide (Glucotrol, XL))- 2nd Gen SU = Increase insulin secretion
Glimepiride (Amyryl))- 2nd Gen SU = Increase insulin secretion
Repaglinide (Prandin)= Increase insulin secretion
Nateglinide (Starlix)= Increase insulin secretion
Metformin (Glucophage and XR= Glucophage, Fortamet,Solution = Riomet) = Insulin sensitizer
Pioglitazone (Actos) = TZD is insulin sensitizer
Rosiglitazone (Avandia) = TZD is insulin sensitizer
Acarbose (Precose) = AGI = Enzyme inhibitors
Miglitol (Glyset) = AGI = Enzyme inhibitors
Humalog@ (Lipro) = Rapid acting Insulin
Novolog@ (Aspart) = Rapid acting Insulin
Apidra@ (Glulisine) = Rapid acting Insulin
Humulin@ (Regular) = Short Acting
Novolin@ (Regular) = Short acting
Lantus@ (Glargin) = Long acting insulin
Levemir@ (Determir) = LA insulin
Exenatide (Byetta) - GPL-1 agonist = improve beta cell unction and resistance to DDP-4
Sitagliptin (Januvia) - PO = DPP4-inhibitors --> prlong action GLP-1. RD adjustment
Dawn effect Hyperglycemia in AP --> Increase qHS dose of basal insulin OR move from pre-dinner to qHS
Somygyi's effect Hypoglycemia --> check BG at 3 a.m to see if hypoglycemia is present --> decrease pre-dinner or qHS dose of basal insulin
Glucovance@ Glyburide/Metformin
Metaglip@ Glipizide/Metformin
Avandaryl@ Glimepride/Rosiglitazone
Actoplus Met@ Metformin/Pioglitazone
Janumet@ Sitagliptin/Metformin
Humalog 75/25 75 NPH + 25 Lispro
Novolog 70/30 70 AP + 30 Aspart
NPH Intermediate (12 hours)
Humulin 70/30 70 NPH + 30 Regular
Novolin 70/30 70 NPH + 30 Regular
Humulin 50/50 50 NPH + 50 Regular
Diabetese of 2h-OGTT glucose >=200 (normal <140)
FPG diabetes >=126 (normal <100)
Cloudy Insulin? NPH, Lente and Ultralente
Created by: _Tom_
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