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Myeloproliferative disorders

Abnormal clone of hematopoietic stem cells resulting in increased RBC's, granulocytes, mast cells, and platelets. JAK2 mutation positive. Polycythemia vera
Increased histamine results in ruddy face, pruritis, PUD, and GOUT. Polycythemia vera
Clonal proliferation of megakaryocytes. Essential thrombocytopenia
Thrombocytosis with abnormal morphology and dysfunctional platelets. Essential thrombocytopenia
Fibrotic obliteration of bone marrow Myelofibrosis
Normocytic anemia with tear drop cells Myelofibrosis
Leukoerythroblastic reaction with cells tinted blue Myelofibrosis
Increased WBC's and platelets, decreased RBC's CML
Mutation doesn't involve JAK2 gene CML
Created by: csevilla