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Oncology
Leukemias
| Question | Answer |
|---|---|
| Seen in children | ALL |
| TdT+ | ALL |
| Most responsive to therapy | ALL |
| May spread to CNS and testes | ALL |
| Auer rods | AML |
| Responds to all-trans retinoic acid | M3 AML |
| Most common leukemia in children | ALL |
| Most common leukemia overall | CLL |
| Seen in elderly >60 years old | CLL |
| Generally indolent course | CLL |
| Smudge cells | CLL |
| Warm IgG autoimmune hemolytic anemia | CLL |
| Very similar to small lymphocytic lymphoma | CLL |
| Philadelphia chromosome t(9;22), bcr-abl | CML |
| Blast crisis | CML |
| Low leukocyte alkaline phosphatase | CML |
| Responds to imatinib | CML |
| Stains TRAP positive | Hairy T cell leukemia |
| Only leukemia without lymphadenopathy | Hairy T cell leukemia |
| Lymphoblasts predominate (pre-B or pre-T) | ALL |
| Myeloblasts predominate | AML |
| Lymphocytes predominate with non-antibody producing B cells | CLL |
| Myeloid stem cells predominate | CML |