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Path T3-Eponyms

PathT3Eponyms- Brain,Liver,GI

CNS Tumor: Pseudopalisading around zones of necrosis Glioblastoma Multiforme
CNS Tumor: fried-egg appearance Oligodendroglioma
CNS Tumor: Rosenthal Fibers Pilocytic Astrocytomas
CNS Tumor: LOH1p, LOH1q Pilocytic Astrocytomas, respond favorably to chemo.
CNS Tumor: rostettes, perivascular pseudorosettes Ependyoma
CNS Tumor: whorls Meningioma
CNS Tumor: psammoma bodies Meningioma
Plexiform Neurofibroma Pathognomonic for von Recklinghausen's Disease
Charcot-Bouchard Aneurysms microaneurysms in the brain.
Lewy Bodies Seen in Parkinsons.
Glial Cytoplasmic Inclusions Seen in all of the Multiple System Atrophy disorders
Negri Body Rabies.
Increased IgG with oligoclonal bands Seen in MS.
rapidly eveolving quadriplegia Central Pontine Myelinosis
Arnold-Chiari Type II malformation Seen in myelomeningocele (Spina Bifida). Elongation of vermis and brain stem b/c of their displacement into spinal cord, and see hydrocephalus.
Mallory Bodies Seen in Alcoholic Hepatitis
cobblestone appearance in liver Chronic non-progressive (persistent) hepatitis
bridging necrosis with piecemeal necrosis Chronic progressive (active) hepatitis
Anti-smooth muscle and ANA Type 1 Autoimmune Hepatitis
Anti-LKM-1 Type 2 Autoimmune Hepatitis
Antimitochondrial antibodies (AMAs) Primary Biliary Cirrhosis
C282Y mutation Hemochromatosis
PAS+ diastase-resistant globules in hepatocytes Alpha-1-Antitrypsin Deficiency
Beading' on radiography Primary Sclerosing Cholangitis
Kayser-Fleischer Ring Wilsons Disease
Bronze Diabetes Hemochromatosis
Macrophage cytoplasm contains PAS+ granules Whipple's Disease
Zollinger-Ellison Syndrome Gastrin-producing tumor. Causes PUD.
Florid duct lesion Primary Biliary Cirrhosis
NOD2 mutation implicated in Chron's Disease
pANCA found in 75% of Ulcerative Colitis, 11% of Chron's Disease
ASCA (anti-saccharomyces cerevisiae) elevated in Chron's Disease
string sign/skip lesion Chron's Disease
linitis plastica leather-bottle stomach - Stomach Cancer
Krukenberg Tumor Met of stomach cancer to ovary
Saw-toother/Serrated profile Hyperplastic polyps of colon
pedunculated with slender stalk and rasberry-like heads Tubular adenoma (neoplastic polyp)
picket fence appearance Tubular adenoma (neoplastic polyp)
APC gene mutation Familial Adenomatous Polyposis.
Gardner Syndrome FAP + fibromatosis
Turcot Syndrome FAP + Tumors of the CNS
Lynch Syndrome aka HNPCC
PRSS1/SPINK1 mutations Acute Pancreatitis
K-RAS, p16 gene Pancreatic Carcinoma
Trousseau Sign Migratory Thrombophlebitis seen in Pancreatic Carcinoma
CA19-9 serum marker used for diagnosis and follow-up of Pancreatic Carcinoma
Whipple Operation pancreatoduodenectomy - done in pancreatic carcinoma
fat, female, forty, fertile Gallstones! - specifically cholesterol stones.
Porcelain Bladder Ca2+ deposit in gallbladder wall in Acute Cholecystitis
Rokitansky-Aschoff Sinuses Seen in Chronic Cholecystitis
Strawberry Gallbladder Cholesterolosis - focal accumulation of cholesterol-laden macrophages in mucosa
Mallory-Weiss Syndrome Tears in gastroesophageal junction…alcoholics…vomitting
volcano-like/mushroom-like pseudomembrane formation seen in Pseudomembranous Colitis (caused by C. difficile - atb-associated colitis)
most common cause of Intestinal obstruction adhesions
5-HIAA in urine test for Carcinoid Syndrome
Whipple's Triad Seen in Insulinomas: attacks preciptated by fasting, low blood sugars, relieved by glucose.
RET protooncogene on chromosome 10 responsible for MEN 2 and 3.
Conns Syndrome aldosterone secreting adenoma
Addison's Disease destruction of adrenal cortex. Addisons = Adrenal Atrophy with Absence of All cortical hormones
Stalk Effect elevation of serum prolactin due to interference of normal inhibition (dopamine). Any suprasellar mass can cause this
Sheehans Syndrome postpartum pituitary necrosis. Anterior lobes double in size during pregnancy without increase in blood supply. Can see infarction due to obstetrical complications. Hypopituitarism.
Plummers Syndrome Toxic multinodular goiter.
Struma Ovarii Ovarian teratoma with ectopic thyroid
Cretinism caused by hypothyroidism in the young - mental retardation, short stature etc.
Hurthle Cells seen in Hashimotos Thyroiditis (AI primary hypothyroidism)
Little orphan annie eyes Papillary carcinoma of the thyroid
psammoma bodies Papillary carcinoma of the thyroid (also seen in Meningioma - CNS tumor)
Created by: mcafej02



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