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Path T3-Eponyms
PathT3Eponyms- Brain,Liver,GI
| Question | Answer |
|---|---|
| CNS Tumor: Pseudopalisading around zones of necrosis | Glioblastoma Multiforme |
| CNS Tumor: fried-egg appearance | Oligodendroglioma |
| CNS Tumor: Rosenthal Fibers | Pilocytic Astrocytomas |
| CNS Tumor: LOH1p, LOH1q | Pilocytic Astrocytomas, respond favorably to chemo. |
| CNS Tumor: rostettes, perivascular pseudorosettes | Ependyoma |
| CNS Tumor: whorls | Meningioma |
| CNS Tumor: psammoma bodies | Meningioma |
| Plexiform Neurofibroma | Pathognomonic for von Recklinghausen's Disease |
| Charcot-Bouchard Aneurysms | microaneurysms in the brain. |
| Lewy Bodies | Seen in Parkinsons. |
| Glial Cytoplasmic Inclusions | Seen in all of the Multiple System Atrophy disorders |
| Negri Body | Rabies. |
| Increased IgG with oligoclonal bands | Seen in MS. |
| rapidly eveolving quadriplegia | Central Pontine Myelinosis |
| Arnold-Chiari Type II malformation | Seen in myelomeningocele (Spina Bifida). Elongation of vermis and brain stem b/c of their displacement into spinal cord, and see hydrocephalus. |
| Mallory Bodies | Seen in Alcoholic Hepatitis |
| cobblestone appearance in liver | Chronic non-progressive (persistent) hepatitis |
| bridging necrosis with piecemeal necrosis | Chronic progressive (active) hepatitis |
| Anti-smooth muscle and ANA | Type 1 Autoimmune Hepatitis |
| Anti-LKM-1 | Type 2 Autoimmune Hepatitis |
| Antimitochondrial antibodies (AMAs) | Primary Biliary Cirrhosis |
| C282Y mutation | Hemochromatosis |
| PAS+ diastase-resistant globules in hepatocytes | Alpha-1-Antitrypsin Deficiency |
| Beading' on radiography | Primary Sclerosing Cholangitis |
| Kayser-Fleischer Ring | Wilsons Disease |
| Bronze Diabetes | Hemochromatosis |
| Macrophage cytoplasm contains PAS+ granules | Whipple's Disease |
| Zollinger-Ellison Syndrome | Gastrin-producing tumor. Causes PUD. |
| Florid duct lesion | Primary Biliary Cirrhosis |
| NOD2 mutation | implicated in Chron's Disease |
| pANCA | found in 75% of Ulcerative Colitis, 11% of Chron's Disease |
| ASCA (anti-saccharomyces cerevisiae) | elevated in Chron's Disease |
| string sign/skip lesion | Chron's Disease |
| linitis plastica | leather-bottle stomach - Stomach Cancer |
| Krukenberg Tumor | Met of stomach cancer to ovary |
| Saw-toother/Serrated profile | Hyperplastic polyps of colon |
| pedunculated with slender stalk and rasberry-like heads | Tubular adenoma (neoplastic polyp) |
| picket fence appearance | Tubular adenoma (neoplastic polyp) |
| APC gene mutation | Familial Adenomatous Polyposis. |
| Gardner Syndrome | FAP + fibromatosis |
| Turcot Syndrome | FAP + Tumors of the CNS |
| Lynch Syndrome | aka HNPCC |
| PRSS1/SPINK1 mutations | Acute Pancreatitis |
| K-RAS, p16 gene | Pancreatic Carcinoma |
| Trousseau Sign | Migratory Thrombophlebitis seen in Pancreatic Carcinoma |
| CA19-9 | serum marker used for diagnosis and follow-up of Pancreatic Carcinoma |
| Whipple Operation | pancreatoduodenectomy - done in pancreatic carcinoma |
| fat, female, forty, fertile | Gallstones! - specifically cholesterol stones. |
| Porcelain Bladder | Ca2+ deposit in gallbladder wall in Acute Cholecystitis |
| Rokitansky-Aschoff Sinuses | Seen in Chronic Cholecystitis |
| Strawberry Gallbladder | Cholesterolosis - focal accumulation of cholesterol-laden macrophages in mucosa |
| Mallory-Weiss Syndrome | Tears in gastroesophageal junction…alcoholics…vomitting |
| volcano-like/mushroom-like pseudomembrane formation | seen in Pseudomembranous Colitis (caused by C. difficile - atb-associated colitis) |
| most common cause of Intestinal obstruction | adhesions |
| 5-HIAA in urine | test for Carcinoid Syndrome |
| Whipple's Triad | Seen in Insulinomas: attacks preciptated by fasting, low blood sugars, relieved by glucose. |
| RET protooncogene on chromosome 10 | responsible for MEN 2 and 3. |
| Conns Syndrome | aldosterone secreting adenoma |
| Addison's Disease | destruction of adrenal cortex. Addisons = Adrenal Atrophy with Absence of All cortical hormones |
| Stalk Effect | elevation of serum prolactin due to interference of normal inhibition (dopamine). Any suprasellar mass can cause this |
| Sheehans Syndrome | postpartum pituitary necrosis. Anterior lobes double in size during pregnancy without increase in blood supply. Can see infarction due to obstetrical complications. Hypopituitarism. |
| Plummers Syndrome | Toxic multinodular goiter. |
| Struma Ovarii | Ovarian teratoma with ectopic thyroid |
| Cretinism | caused by hypothyroidism in the young - mental retardation, short stature etc. |
| Hurthle Cells | seen in Hashimotos Thyroiditis (AI primary hypothyroidism) |
| Little orphan annie eyes | Papillary carcinoma of the thyroid |
| psammoma bodies | Papillary carcinoma of the thyroid (also seen in Meningioma - CNS tumor) |
Created by:
mcafej02
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