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BIM Final Review 2

Lecture 4: Cells and TE

Autograft From me to me
Limitations of autografts Limited availability, donor site morbidity
Allograft From you to me, within same species
Limitations of autografts Immune rejection, disease transfer
Xenograft From something else to me, different species
Limitations of xenografts Host integration, disease transfer
Materials Synthetic, ceramic, metals
Limitations of materials Inflammatory response, vascular barrier
Tissue engineering Combine living cells and biomaterials or use living cells as therapeutic or diagnostic agents Generate cells or tissues in vitro for in vivo therapeutic implantation Enable biomaterials and technology for any of the above
Tissue engineering paradigm Cells, biologically active factors, biomaterials
Somatic cells Fully differentiated cells within developed tissues – often used for TE
Bone cells Osteoblasts
Heart cells Cardiomyocytes
Skin cells Keratinocytes, fibroblasts
Muscle cells Myoblasts
Additive manufacturing 3D printing Can 3D print synthetic polymers, naturally derive polymeric materials, tissue ECM, cells
Biomedical engineers advance tissue engineering Biomaterials design, bioreactors/mechanical stimulation, novel culture environments, controlled drug delivery
Successful advances require collaborations Biologists, pharmacologists, materials science, clinicians
Created by: 1543931625634163