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BIM Final Review 2
Lecture 4: Cells and TE
Question | Answer |
---|---|
Autograft | From me to me |
Limitations of autografts | Limited availability, donor site morbidity |
Allograft | From you to me, within same species |
Limitations of autografts | Immune rejection, disease transfer |
Xenograft | From something else to me, different species |
Limitations of xenografts | Host integration, disease transfer |
Materials | Synthetic, ceramic, metals |
Limitations of materials | Inflammatory response, vascular barrier |
Tissue engineering | Combine living cells and biomaterials or use living cells as therapeutic or diagnostic agents Generate cells or tissues in vitro for in vivo therapeutic implantation Enable biomaterials and technology for any of the above |
Tissue engineering paradigm | Cells, biologically active factors, biomaterials |
Somatic cells | Fully differentiated cells within developed tissues – often used for TE |
Bone cells | Osteoblasts |
Heart cells | Cardiomyocytes |
Skin cells | Keratinocytes, fibroblasts |
Muscle cells | Myoblasts |
Additive manufacturing | 3D printing Can 3D print synthetic polymers, naturally derive polymeric materials, tissue ECM, cells |
Biomedical engineers advance tissue engineering | Biomaterials design, bioreactors/mechanical stimulation, novel culture environments, controlled drug delivery |
Successful advances require collaborations | Biologists, pharmacologists, materials science, clinicians |