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Endotoxins

Microbio

QuestionAnswer
Endotoxins are produced by ____ bacteria. They are made of ____. Gram negative; LPS
Endotoxins cause 3 events: 1. Activate macrophages, 2. Activate complement (alternate pathway), 3. Activate Hageman factor
Activation of macrophages causes: IL-1 (fever), TNF (fever, hemorrhagic tissue necrosis), Nitric oxide (Hypotension, ie. shock)
Activation of the complement (alternate pathway) produces the release of ___ and___. C3a (hypotension and edema), C5a (Neutrophil chemotaxis)
Activation of Hageman factor activates Coagulation cascade (DIC)
Overall endotoxins cause Fever (Il-1, TNF), Hypotension (NO, C3a), Movement of neutrophils (C5a), activation of coagulation cascade (Hageman factor)
Created by: ddecampo
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