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OPT Bone Pathology

osteogenesis imperfecta heritable CT disorders of osteopenia and bone fragility due to mutation of type I collagen
osteopetrosis (marble bone disease) increase in bone density due to failure of normal osteoclasts
infantile osteopetrosis presents at birth and termed {malignant osteopetrosis} due to severity; widespread osteosclerosis, marrow failure and fractures
intermediate osteopetrosis less severe form of osteopetrosis with fractures by age 10, osteomyelitis for dental procedures
adult osteopetrosis most common type of osteopetrosis, milder and usually not life-threatening aka {benign osteopetrosis}
cleidocranial dysplasia bone pathosis caused by mutation that guides osteoblastic differentiation, chondrocytic maturation and bone formation; large head, sometimes missing clavicles, supernumerary teeth
focal osteoporotic marrow defect area of hematopoietic marrow big enough to be radiolucent and can be confused with intrabony neoplasm; often in posterior mandible after extraction
idiopathic osteosclerosis (enostosis) areas of sclerotic bone unrelated to disease or cancer
massive osteolysis (Gotham disease, vanishing bone disease) idiopathic destruction of bone, most commonly in the jaws; large areas of radiolucency, mobile teeth, pain and malocclusion
Paget disease of bone (osteitis deformans) abnormal resorption and deposition of bone resulting in distortion and weakening of bones; bone pain and increased prevalence of osteosarcomas
leontiasis ossea maxillary involvement results in lion-like facial deformity
osteoporosis circumscripta area of bone radiolucency that develop patchy radiopaque zones in Paget disease
cotton wool pattern of bone on radiograph of radiolucencies and patches of radiopacity coalescing into large sclerosing areas; in Paget disease
black beard / Lincoln's sign bone scan exhibits marked uptake from condyle to condyle in Paget disease
jigsaw puzzle or mosaic pattern histologic pattern of bone with haphazard arrangement and reversal lines in Paget disease
central giant cell granuloma intrabony proliferation of osteoclastic multinucleated giant cells; unclear is a reactive lesion or neoplasm
giant cell tumor similar to central giant cell granuloma that occurs in long bones; high cellularity and aggressiveness
cherubism autosomal dominant disorder of giant cell granulomas in posterior mandible causing large jaws in kids
simple bone cyst (traumatic bone cyst) benign cavity in bone without epithelial lining, can be due to trauma or idiopathic
aneurysmal bone cyst intrabony extravasation of RBCs (hematoma) surrounded by cellular fibrous connective tissue; radiolucency with cortical expansion
fibrous dysplasia localized replacement of bone by cellular fibrous connective tissue and less organized bone; can occur with cafe-au-lait pigmentations and radiographs have {ground glass} appearance
monostotic fibrous dysplasia involvement of fibrous dysplasia is limited to single bone without any predilections
Jaffe-Lichtenstein syndrome polyostotic fibrous dysplastic lesions; late fetal mutation
McCune-Albright syndrome polyostotic fibrous dysplasia with endocrine hyperfunction
Mazabraud syndrome fibrous dysplasia combined with intramuscular myxomas
craniofacial fibrous dysplasia maxillary fibous dysplasia lesions that cross suture lines
Chinese characters histopathologic appearance of fibrous dysplasia; fibrous connective tissue mixed with curvilineartrabeculae of cellular woven bone
cemento-osseous dysplasia most common fibro-osseous lesion; mixture of CT and bone in tooth-bearing areas of jaws
focal cemento-osseous dysplasia 90% in females, begin as radiolucency and progress to radiopacity surrounded by radiolucent ring
periapical cemento-osseous dysplasia multifocal cemento-osseous lesions in anterior mandible; in blacks and females
florid cemento-osseous dysplasia similar to periapical cemento-osseous dysplasia but not restricted to the anterior mandible; in blacks and females
familial gigantiform cementoma autosomal dominant disorder of disfiguring masses of fibro-osseous tissue
ossifying fibroma true neoplasm of cellular fibrous CT mixed with cellular woven bone and cemental-like mineralization
juvenile ossifying fibroma rapid growing ossifying fibroma in young adults
osteoma benign tumor of mature compact / cancellous bone; opacity with no lucent rim
Gardner syndrome autosomal dominant variant of familial adenomatous polyposis, secondary to mutation of APC gene; colon polyps and osteomas
osteoblastoma true neoplasm of osteoblasts, histologically identical to cementoblastoma and often painful
osteioid osteoma name for osteoblastoma under 2 cm in size
cementoblastoma odontogenic tumor of cementoblasts directly attached to teeth and encased by PDL
chondroma benign tumor of mature hyaline cartilage; if found in jaws, usually chondrosarcoma
osteosarcoma (osteogenic sarcoma) malignancy of mesenchymal cells that produce osteoid; sunburst pattern on occlusal radiographs
post-radiation osteosarcoma follows therapeutic radiation in head and neck; usually 4-17 year latency
peripheral (juxtacortical) osteosarcoma osteosarcoma that arises from the surface of bone and grows outward
parosteal type of osteosarcoma with surface origin without periosteal involvement
periosteal type of osteosarcoma that arises between the cortex and periosteum, elevates the periosteum
chondrosarcoma malignant tumor that forms cartilage, can calcify
Ewing sarcoma primary malignant tumor of bone composed of small, undifferentiated round cells in kids; frequently metastasizes to lung, liver and lymph nodes
metastatic carcinoma most common form of cancer involving the bone, most commonly the vertebrae, ribs, pelvis and skull
numb-chin syndrome bone metastases in mandible and alveolar canal can produce loss of sensation in lip and chin
Created by: aharnold



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