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Immune System Parts

Shawnee ADNR193 Immune Stuff

Inflammation a non-specific reaction that is immediate and provides short-term protection
Neutrophils compromise 55-70% of WBC, mature in bone marrow, first line of defense, perform phagocytosis
Macrophages created from monocytes that are released from bone marrow, life span is months to years, perform phagocytosis, repair of injured tissue, antigen processing, and secretions of cytokines
Basophils smallest and rarest of WBC, release heparin and vasoactive substances
Eosinophils compromise 1-2% of total WBC, posess weak phagocytic activity, release vasoactive substances
B-Lymphocytes(Antibody-Mediated) cell with the most direct role, requires assistance from macrophages
T-lymphocytes(Antibody-Meidated) produce helper T cells to regulate B lymphocytes
Agglutination binding of more than 1 antigen to antibody; slows the movement of antigen through the blood so other WBC's may attack it
Lysis antibody attaches to membrane surface antigens, esp. bacteria/viruses
Complement Fixation IgG and IgM stimulate complement cascade
Precipitation Large complex removed by other WBC's
Inactivation/Neutralization antibody cover antigen's active site and renders it useless
IgG most abundant antibody in blood, activates complement, neutralizes toxins, enhances phagocytosis, and provides immunity against viral and bacterial infections
IgM approx. 10% in blood, activates complement, clears antigen through precipitation, possibly mediates autoimmune reactions, responsible for ABO blood transfusion incompatability
IgA less than 15% content in blood, secretory anitbody found in various body secretions, inhibits bacteria and viruses from adhering to skin and mucous membranes
IgE less than 1% in blood, degranulation of basophils during inflammatory response, helps clear parasites and prevent respiratory infections, and mediates many hypersensitivity reactions
IgD less than 1% in blood and modifies IgM activity
Innate Immunity genetically determined, person either does or does not have immunity
Aquired Immunity adaptive response to an invasion of antigen, occurs naturally or artificially
Active Immunity antigen enters body and body responds by making antigens against it
Natural Active Immunity occurs w/o human assistance, person has the disease, most effective and longest lasting immunity
Artificial Active Immunity a small amount of antigen introduced so the body will produce antibodies. ex. vaccinations
Passive Immunity antibodies introduced into the body but the body did not produce them, provides immediate and short-term protection
Natural Passive Immunity provided by mother to fetus across the placenta
Artificial Passive Immunity antibodies delibrately injected into a person when a person is exposed to serious disease and has no immunity
Helper T cell efficient in recognizing self vs. non-self, secrete lymphokines which regulate activity of other leukocytes, and stimulate and organize the response of total immune system
T suppressor cell prevent overstimulation of immune response, have an inhibitory effect on the immune response
Cytotoxic T cell bind to HLA antigen complex cell and kill it
NK cells "search and destroy" mission throughout the body
Primary Immunodeficiency A deficient response that's due to a missing component in the immune response. Has gentic or developmental cause
Secondary Immunodeficiency an aquired disease in, or lack of, an immune response as the result of an underlying cause or dysfunction outside of the immune system
Created by: rsg175