Busy. Please wait.

show password
Forgot Password?

Don't have an account?  Sign up 

Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
We do not share your email address with others. It is only used to allow you to reset your password. For details read our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

USMLE pharm

Pharm general principles/equations etc.

high Km = High/low affinity High Km = low affinity
Changing substrate concentrations changes Km T/F False. Km will not change with a change in substrate concentrations
In Lineweaver burk plot: Increasing Vmax has what effect? Increasing Vmax = decrease in y intercept
In Lineweaver burk plot, increasing Km (decreasing ___) will have what effect? Decrease affinity; will cause the X-intercept to move to teh right
Vd Amount of drug in body compared to the plasma concentration. (Amt drug/plasma conc) or Dose/Co.
Low Vd, Medium Vd, High Vd. Low vd = 4-8 L, Medium = (body water), High Vd = > body weight; distributes in tissue
Clearance (CL) Relates teh rate of elimination to the plasma concentration. (Rate of elimination/plasma concentration) OR Vdx Ke, where Ke = elimination constant
Half life Time required to change the amount of drug in the body by 1/2 during elimination. t = 0.7x Vd/Cl= 0.7/Ke
Loading dose (Cp x Vd)/F where Cp (target plasma concentration), F = bioavailability
Maintenance dose (Cp x CL)/F, where CP = target plasma concentration
How do liver/kidney disease affect pharmacology 1. Can change the volume of distribution, 2. Maintenance dose will decrease, but loading dose will remain the same
How does infusion concentration affect steady state 1. will not affect time to reach steady state but can affect concentration at steady state
Drugs that exhibit zero-order elimination PEA Phenytoin, Ethanol, Aspirin (will decrease at a constant amount/unit time)
Maximal effect a drug can have Efficacy
Amount of drug needed for a given effect Potency
How do competitive agonists affect potency/efficacy? Cause a decrease in potency
How do non-competitive agonists affect potency/efficacy? Decrease efficacy
Created by: ddecampo



Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
restart all cards