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USMLE Drug reactions

Drug reactionCausal agent
Atropine-like side effects Tricyclics
Coronary vasospasm cocaine, sumatriptan
Cutaneous flushing Niacin, Ca channel blockers, adenosine, vancomycin
Dilated cardiomyopathy Doxorubicin (adriamycin), daunorubicin
Torsades de pointes Class III (sotalol), Class IA (quinidine), antiarrythmics, cisapride
Agranulocytosis Clozapine, carbamazepine, colchicine, propylthiouracil, methimazole
Aplastic anemia chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole
Direct Coomb-positive hemolytic anemia Methyldopa
Gray babe syndrome Chloramphenicol
Hemolysis in G6PD-deficient patients Hemolysis (IS PAIN) Isoniazid, Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin
Megablastic Anemia Phenytoin, Methotrexate, Sulfa drugs (having a BLAST with PMS)
Thrombotic complications OCPs (estrogen and progestin)
Cough ACE inhibitors
Pulmonary fibrosis Bleomycin, busulfan, amiodarone
Acute cholestatic hepatitis Macrolides
Focal-massive hepatic necrosis Halothane, valproic acid, acetaminophen, Amanita phalloides
Hepatitis INH
Pseudomembranous colitis Clindamycin, ampicillin
Adrenocortical insufficiency Glucocorticoid withdrawl (HPA suppression)
Gynecomastia (Some Drugs Create Awesome Knockers) Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole
Hot flashes Tamoxifen, clomiphene
Gingival hyper plasia Phenytoin
Gout Furosemide, Thiazides
Osteoperosis Corticosteroids, heparin
Photosensitivity, (SAT for a PHOTO) Sulfonamides, Amiodarone, Tetracycline
Rash (Stevens-Johnson syndrome) Ethosuximide, lamotrigine, carbamazepine, phenobarbital, phenytoin, sulfa drugs,penicillin, allopurinol
SLE-like syndrome, (it's not HIPP to have lupus) Hydralazine, INH, Procainamide, Phenytoin
Tendonitis, tendon rupture, cartilage damage Fluroquinolones
Fanconi's syndrome expired tetracycline
Interstitial nephritis Methicillin, NSAIDs, furosemide
Hemorrhagic cystitis cyclophosphamide, ifosfamide (coadminister mesna)
Cinchonism Quinidine, quinine
Diabetes insipidus lithium, democlocycline
Parkinson-like syndrome haloperidol, chlorpromazine, reserpine, metoclopramide
Seizures Bupropion, imipenem/cilastatin, isoniazid
Tardive dyskinesia antipsychotics
Disulfiram-like reaction metronidazole, certain cephalosporins, procarbazine, 1st generation sulfonylureas
Nephrotoxicity/neurotoxicity polymyxins
Nephrotoxicity/ototoxicity aminoglycosides, vancomycin, loop diuretics, cisplatin
Created by: ddecampo