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Oncology – ABIM

Non-small cell and small cell lung cancer

QuestionAnswer
What is the treatment for non-small cell lung cancer if tumor is greater than 2 cm away from the carina and there is no lymph node involvement? Surgery and chemo
What is the treatment for non-small cell lung cancer if the tumor is greater than 2 cm away from the carina and there is ipsilateral lymph node involvement? Surgery and chemo
In non-small cell lung cancer, which patients get surgery and chemo only? Patients whose tumor is greater than 2 cm away from the carina and disease that does not cross the midline.
What is the treatment in non-small cell lung carcinoma when the tumor is less than 2 cm away from the carina and there is ipsilateral lymph node involvement? Surgery, chemo, radiation
What is the treatment and non-small cell lung carcinoma when the tumor is less than 2 cm away from the carina and there is contralateral lymph node involvement? Chemo and radiation
What automatically takes surgery out of the treatment option for non-small cell lung carcinoma? involvement of a contralateral or right supra-clavicular lymph node
What is the treatment for non-small cell lung carcinoma when there is right supra clavicular node involvement? Chemotherapy – erlotinib and gefitinib
What is the treatment for non-small cell lung carcinoma when there is a pleural effusion composed of malignant cells? Chemotherapy – erlotinib and gefitinib
In small cell lung carcinoma, what is the treatment when one hemi thorax is involved? Chemo, brain radiation, lung radiation
In small cell lung carcinoma, what is the treatment when there is extensive disease? Chemo and brain radiation
What is the treatment for small cell lung carcinoma in an elderly person? Chemo and brain radiation
What is the mechanism of erlotinib? inhibits overall epidermal growth factor receptor (HER1/EGFR) - tyrosine kinase activity --> cell death
What should happen after the resection of a non-small cell tumor? Check for EGFR/HER2 mutation to decide whether we can use EGFR tyrosine kinase inhibitor
What to treat with if a patient has progression of non-small cell lung carcinoma despite cisplatin-based chemotherapy? nivolumab, a programmed cell death 1 (PD-1) inhibitor The PD-1 gene downregulates the immune system by preventing T-cell activation; it is thought that many malignancies escape immune surveillance via a PD-1–related mechanism.
What does silicosis put you at risk for? Lung cancer and tuberculosis
Created by: christinapham