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morphine Sulfate

Morphine

QuestionAnswer
GENERIC NAME Morphine Sulfate
BRAND NAME Astramorph/pf
CLASS Opioid analgesic (schedule II narcotic)
MECHANISM OF ACTION Alleviates pain through CNS action, Suppresses fear and anxiety centers in brain, depresses brain stem respiratory centers, increases peripheral venous capacitance and decreases venous return, decreases preload, after load, & myocardial oxygen demand.
INDICATIONS Severe CHF, pulmonary edema, chest pain associated with acute MI, analgesia for moderate to severe acute and chronic pain (use with caution)
CONTRAINDICATIONS Head injury, exacerbated COPD, depressed respiratory drive, hypotension, undiagnosed abdominal pain, decreased LOC, suspected hypovolemia, patients who have taken MAOIs within the past 14 days.
ADVERSE REACTIONS Respiratory depression, hypotension, decreased LOC, nausea, vomiting, Bradycardia, tachycardia, syncope, facial flushing, euphoria, bronchospasm, dry mouth.
NOTES ON ADMINISTRATION Pregnancy Category C. Morphine rapidly crosses the placenta. Safety in neonate not established. Use with caution in geriatric population COPD, & asthma. Vagotonic effect in patient with acute inferior MI (Bradycardia, heart block).
INCOMPATABILITIES/DRUG INTERACTIONS Potentiates sedative effects of phenothiazines. CNS depressant may potentiate effects of morphine. MAOIs may cause paradoxical excitation.
DOSE/ROUTE, Adult Initial dose
DOSE/ROUTE Pediatric .1-.2 mg/kg per dose via IV. IO. IM, or SC; Maximum dose of 5mg.
ONSET OF ACTION Immediate
PEAK EFFECTS 20 minutes
DURATION OF ACTION 2-7 hours
AZ DRUG BOX SUPPLY RANGE 20mg
Created by: klindley