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Diazepam

QuestionAnswer
GENERIC NAME Diazepam
BRAND NAME Valium
CLASS Benzodiazepine, sedative hypnotic, anticonvulsant
MECHANISM OF ACTION Potentiates effects of inhibitory neurotransmitters. Raises seizure threshold. Induces amnesia and sedation.
INDICATIONS Acute anxiety states, acute alcohol withdrawal, muscle relaxant, seizure activity, agitation. Analgesia for medical procedures.
CONTRAINDICATIONS Hypersensitivity, glaucoma, coma, shock, substance abuse, head injury
ADVERSE REACTIONS Respiratory depression, hypotension. Drowsiness, ataxia, Reflex tachycardia, nausea, confusion, thrombosis, and phlebitis.
NOTES ON ADMINISTRATION Pregnancy category D. Reduce dose 50% in elderly patients.
INCOMPATABILITIES/DRUG INTERACTIONS Incompatible with most drugs, fluids.
DOSE/ROUTE Adult, seizure activity 5-10mg IV q 10-15 minutes prn. Max dose 30mg.
Pediatric, seizure activity 0.2-0.5mg slowly q 2-5 minutes up to 5mg. max dose 10mg/kg.
Pediatric, rectally 0.5 mg/kg via 2’’ rectal catheter and flush with 2-3ml of air after administration.
Adult, cardioversion sedation 5-15mg IV over 5-10 minutes prior to cardioversion.
ONSET OF ACTION 1-5 minutes
PEAK EFFECTS Minutes
DURATION OF ACTION 20-50 minutes
AZ DRUG BOX SUPPLY RANGE 20mg. Rectal 20mg (optional)
Created by: klindley