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Thiamine

thiamine

QuestionAnswer
GENERIC NAME None
BRAND NAME Thiamine
CLASS Vitamin B1
MECHANISM OF ACTION Combines with ATP to form thiamine pyrophosphate coenzyme, a necessary component for carbohydrate metabolism. The brain is extremely sensitive to thiamine deficiency.
INDICATIONS Coma of unknown origin, delirium tremens, beriberi, Wernicke’s encephalopathy.
CONTRAINDICATIONS None
ADVERSE REACTIONS Hypotension from to rapid of an injection or to high of a dose, anxiety, diaphoresis, N/V or hypersensitivity.
NOTES ON ADMINISTRATION Pregnancy category A. Large IV doses may cause respiratory difficulties. Anaphylaxis reactions reported.
INCOMPATABILITIES/DRUG INTERACTIONS Give thiamine before glucose under all circumstances.
DOSE/ROUTE Adult
Pediatric 10-25mg slow IV, or IM
ONSET OF ACTION Rapid
PEAK EFFECTS Variable
DURATION OF ACTION Dependent upon degree of deficiency
AZ DRUG BOX SUPPLY RANGE 100mg
Created by: klindley