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Residency ECC

What is the mechanism of polyuria in dogs with hepatic encephalopathy (HE)? It is believed to be due to a hypercortisolemia that is caused by a inhibition of ACTH release from the pituitary gland. It is thought that a cortisol-induced partial inhibition of renal tubular response to vasopressin and thus PU is seen.
Proposed theories for the development of HE? 1) Toxic metabolites from gastrointestinal bacteria were not removed from portal circulation by the liver. 2) Failure of diseased liver to synthesize factors that are necessary for normal brain function.
T or F - The brain is devoid of an effective urea cycle? True - the brain has no Urea cycle to handle any excess urea in the blood
Name a few Toxic gut metabolites that are responsible for HE? Ammonia (NH3), Mercaptan (thiols), Short-chain fatty acids, aromatic amino acids, false neurotransmitters, tryptophan, GABA Agonists, Endogenous benzodiazepines
Created by: Jeannieclark84