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Hormones & Actions

Oxytocin; location(L) & chemical class(C) Stimulates milk ejection from breasts and uterine contractions; P. Pituitary(P.P); Peptide (P)
Vasopressin or antidiuretic hormone (ADH); L & C Stimulates water reabsorption in principal cells of collecting ducts and constriction of arterioles; P.P;P
Triiodothyronine (T3) and L-thyroxine (T4); L&C Stimulates skeletal growth; oxygen consumption; heat production; protein, fat, and carbohydrate utilization; perinatal maturation of CNS; (Thyroid; Amine)
Calcitonin;(L&C) Decreases serum [Ca2+]; (Thyroid &P)
Parathyroid hormone (PTH) ; (L&C) Increases serum [Ca2+]; (Parathyroid& P)
Cortisol (glucocorticoid); (L&C) Stimulates gluconeogenesis; inhibits inflammatory response; suppresses immune response; enhances vascular responsiveness to catecholamines; (Adrenal Cortex&Steroid)
Aldosterone (mineralocorticoid); (L&C) Increases renal Na+ reabsorption, K+ secretion, and H+ secretion (Adrenal Cortex&Steroid)
Dehydroepiandrosterone (DHEA) and androstenedione (adrenal androgens) Stimulates spermatogenesis; stimulates male secondary sex characteristics(Adrenal Cortex&Steroid)
Testosterone Stimulates spermatogenesis; stimulates male secondary sex characteristics(Steroid&Testes)
Estradiol Stimulates growth and development of female reproductive system, follicular phase of menstrual cycle, development of breasts, prolactin secretion; maintains pregnancy (Steroid&Ovaries)
Progesterone Stimulates luteal phase of menstrual cycle; maintains pregnancy(Ovaries&Steroid)
Estradiol and progesterone See actions of estradiol and progesterone from ovaries (see above) (Corpus Luteum&Steroid)
Human chorionic gonadotropin (HCG) Stimulates estrogen and progesterone synthesis in corpus luteum of early pregnancy (Placenta & Peptide)
Human placental lactogen (HPL), or human chorionic somatomammotropin Has growth hormone–like and prolactin-like actions during pregnancy(Placenta & Peptide)
Estriol See actions of estradiol from ovaries (see above)(Placenta&Steroid )
Progesterone See actions of progesterone from ovaries (see above) (Placenta&Steroid)
Insulin ( Beta cells) Decreases blood [glucose]; (Pancreas&Peptide)
Glucagon ( alpha cells) Increases blood [glucose]; (Pancreas&Peptide)
Renin Catalyzes conversion of angiotensinogen to angiotensin I (Kidney& Peptide)
1,25-Dihydroxycholecalciferol Increases intestinal absorption of Ca2+; bone mineralization (Kidney&Steroid)
Norepinephrine, epinephrine See actions of sympathetic nervous system (Adrenal Medulla; Amine)
Somatotroph adenomas Inc. GH prod. and cause acromegaly in adults and gigantism in children
Corticotroph adenomas Prod. adrenocortical-stimulating hormone, ACTH, which causes Cushings disease.
Thyrotroph adenomas Prod. thyroid-stimulating hormone (TSH), leading to thyrotoxicosis. Thyrotroph adenomas are very uncommon.
Gonadotroph adenomas These tumors over produce alph subunits of these glycoprotein hormones, and present with mass effects and hypogonadism. Most nonsecretory adenomas arise from the gonadotrophs. These tumors tend to grow slowly.
5 maj. cell types of Anterior Pituitary gland cells giving rise to tumors *Tum1Lactotrophs (Prolactin): Hypogonadism, Glactorrhea in (F) 2. Corticotrophs (ACTH) Cushings disease **Cell 3. Somatotrophs (GH) Acromegaly & Gigantism in Pedi 4. Thyrotrophs (TSH) Thyrotoxicosis 5. Gonadotrophs (LH/FSH)Hypogonadism & mass effect
Created by: pezeamama12



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