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OPT Respiratory II
Term | Definition |
---|---|
pulmonary thromboembolism | when blood clots from somewhere else in the body (95% come from the deep leg veins) occlude the pulmonary arteries; seen in prolonged bedrest, birthcontrol |
saddle emboli | large embolus that lodges on bifurcation of pulmonary artery causing complete blockage |
acute cor pulmonale | acute dilation of the right heart that can cause sudden death |
pulmonary hypertension | usually secondary to obstructive lung disease, recurrent pulmonary emboli or heart defects (left to right shunts) |
Goodpasture syndrome | glomerulonephritis with interstitial pneumonitis; autoimmune disorder that attacks type IV collagen in basement membranes in kidneys and lungs |
Wegener granulomatosis (pulmonary angiitis and granulomatosis) | group of systemic vasculitides affecting the upper and lower respiratory tract and kidneys |
pneumonia | any infection involving the lung |
bronchopneumonia | patchy distribution of inflammation that involves multiple lobes but little damage to the septa; lung is restored after resolution |
lobar pneumonia | part or all of a lobe is filled with exudate; usually Streptococcus pneumoniae |
primary atypical pneumonia | infections by viruses and mycoplasma that cause inflammation of the interstitial tissues; inflammatory reaction is contained to the alveoli and the alveolar spaces are free of exudate |
Mycoplasma pneumoniae | organism that most commonly causes primary atypical pneumonias |
Streptococcus pneumoniae | aka {pneumococcal pneumonia}; most common cause of community-acquired acute pneumonias and often in lobar pneumonias |
lobar pattern of pneumonia | 1. congestion 2. red hepatization 3. gray hepatization 4. resolution |
fibrinous pleuritis | begins during the red hepatization stage and resolves with the infection |
bronchopneumotic pattern | patchy pattern of inflammation, no pleural involvement |
Haemophilus influenzae | organism that causes acute exacerbation of COPD |
Staphylococcus aureus | organism that causes nosocomial pneumonia and follows some viral respiratory infections |
Klebsiella pneumoniae | Gram- organism that causes bacterial pneumonia in chronic alcoholics |
Legionella pneumophila | agent of {Legionnaire's disease}; lives in artificial water containment and is inhaled, resistant to many antibiotics |
Nosocomial pneumonia | hospital acquired pneumonias |
Pseudomonas aeruginosa | common pathogen associated with nosocomial infections |
aspiration pneumonia | occurs in patients that aspirate gastric contents causing infection |
lung abscess | area of suppurative necrosis in lung parenchyma that forms large cavities; anaerobic bacteria from the mouth can form these |
chronic pneumonia | localized lesion in immunocompromised usually with granulomatous inflammation |
Mycobacterium tuberculosis | causative agent in chronic pneumonias |
tuberculosis | communicable disease caused by {Mycobacterium tuberculosis}; usually an asymptomatic pulmonary infection |
tuberculin (Mantoux) test | detects infection of M. tuberculosis using the allergenic hypersensitivity reaction to tubercular antigens |
purified protein derivative (PPD) | injected intracutaneously and induces visible induration if positive |
caseous necrosis | central necrosis of cheesy necrotic debris |
caseating granulomatous inflammation | type of inflammation seen in tuberculosis and chronic pneumonias |
primary tuberculosis | develops in non-sensitized, previously unexposed people, almost always by inhaling the organism |
Ghon focus | tubercle in the lung |
Ghon complex | tubercles in lungs and lymph nodes |
progressive primary tuberculosis | occurs when primary tuberculosis progresses without interruption; seen in HIV patients, lymphohematogenous dissemination is a dreaded complication |
secondary tuberculosis | reactivation of a primary lesion when the host is weakened |
cavitation | large areas of lung necrosis from continuously growing tubercles |
tuberculous pneumonia | tuberculosis that spreads to involve large areas of the lungs |
miliary tuberculosis | systemically disseminated tuberculosis that occurs once blood vessels become involved |
scrofula | involvement of neck lymph nodes by tuberculosis |
bronchogenic carcinoma | leading cancer death in industrialized countries; from cigarette smoking |
non-small cell lung cancer (NSCLC) | lung cancer best treated by surgery; includes squamous cell carcinomas (smokers) |
small cell lung cancer (SCLC) | lung cancer best treated by chemo because has usually metastasized |
mesothelioma | pleural tumor due to occupational exposure to asbestos; smoking in conjunction with asbestos does not increase the risk of this cancer |
nasopharyngeal carcinoma | linked with Epstein-Barr virus, in Chinese people; non-keratinizing squamous cell carcinoma (undifferentiated) is most common type and very radiosensitive |
carcinoma of the larynx | cancer seen in men, smokers, usually squamous cell carcinomas; persistent hoarseness |