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OPT Respiratory II
| Term | Definition |
|---|---|
| pulmonary thromboembolism | when blood clots from somewhere else in the body (95% come from the deep leg veins) occlude the pulmonary arteries; seen in prolonged bedrest, birthcontrol |
| saddle emboli | large embolus that lodges on bifurcation of pulmonary artery causing complete blockage |
| acute cor pulmonale | acute dilation of the right heart that can cause sudden death |
| pulmonary hypertension | usually secondary to obstructive lung disease, recurrent pulmonary emboli or heart defects (left to right shunts) |
| Goodpasture syndrome | glomerulonephritis with interstitial pneumonitis; autoimmune disorder that attacks type IV collagen in basement membranes in kidneys and lungs |
| Wegener granulomatosis (pulmonary angiitis and granulomatosis) | group of systemic vasculitides affecting the upper and lower respiratory tract and kidneys |
| pneumonia | any infection involving the lung |
| bronchopneumonia | patchy distribution of inflammation that involves multiple lobes but little damage to the septa; lung is restored after resolution |
| lobar pneumonia | part or all of a lobe is filled with exudate; usually Streptococcus pneumoniae |
| primary atypical pneumonia | infections by viruses and mycoplasma that cause inflammation of the interstitial tissues; inflammatory reaction is contained to the alveoli and the alveolar spaces are free of exudate |
| Mycoplasma pneumoniae | organism that most commonly causes primary atypical pneumonias |
| Streptococcus pneumoniae | aka {pneumococcal pneumonia}; most common cause of community-acquired acute pneumonias and often in lobar pneumonias |
| lobar pattern of pneumonia | 1. congestion 2. red hepatization 3. gray hepatization 4. resolution |
| fibrinous pleuritis | begins during the red hepatization stage and resolves with the infection |
| bronchopneumotic pattern | patchy pattern of inflammation, no pleural involvement |
| Haemophilus influenzae | organism that causes acute exacerbation of COPD |
| Staphylococcus aureus | organism that causes nosocomial pneumonia and follows some viral respiratory infections |
| Klebsiella pneumoniae | Gram- organism that causes bacterial pneumonia in chronic alcoholics |
| Legionella pneumophila | agent of {Legionnaire's disease}; lives in artificial water containment and is inhaled, resistant to many antibiotics |
| Nosocomial pneumonia | hospital acquired pneumonias |
| Pseudomonas aeruginosa | common pathogen associated with nosocomial infections |
| aspiration pneumonia | occurs in patients that aspirate gastric contents causing infection |
| lung abscess | area of suppurative necrosis in lung parenchyma that forms large cavities; anaerobic bacteria from the mouth can form these |
| chronic pneumonia | localized lesion in immunocompromised usually with granulomatous inflammation |
| Mycobacterium tuberculosis | causative agent in chronic pneumonias |
| tuberculosis | communicable disease caused by {Mycobacterium tuberculosis}; usually an asymptomatic pulmonary infection |
| tuberculin (Mantoux) test | detects infection of M. tuberculosis using the allergenic hypersensitivity reaction to tubercular antigens |
| purified protein derivative (PPD) | injected intracutaneously and induces visible induration if positive |
| caseous necrosis | central necrosis of cheesy necrotic debris |
| caseating granulomatous inflammation | type of inflammation seen in tuberculosis and chronic pneumonias |
| primary tuberculosis | develops in non-sensitized, previously unexposed people, almost always by inhaling the organism |
| Ghon focus | tubercle in the lung |
| Ghon complex | tubercles in lungs and lymph nodes |
| progressive primary tuberculosis | occurs when primary tuberculosis progresses without interruption; seen in HIV patients, lymphohematogenous dissemination is a dreaded complication |
| secondary tuberculosis | reactivation of a primary lesion when the host is weakened |
| cavitation | large areas of lung necrosis from continuously growing tubercles |
| tuberculous pneumonia | tuberculosis that spreads to involve large areas of the lungs |
| miliary tuberculosis | systemically disseminated tuberculosis that occurs once blood vessels become involved |
| scrofula | involvement of neck lymph nodes by tuberculosis |
| bronchogenic carcinoma | leading cancer death in industrialized countries; from cigarette smoking |
| non-small cell lung cancer (NSCLC) | lung cancer best treated by surgery; includes squamous cell carcinomas (smokers) |
| small cell lung cancer (SCLC) | lung cancer best treated by chemo because has usually metastasized |
| mesothelioma | pleural tumor due to occupational exposure to asbestos; smoking in conjunction with asbestos does not increase the risk of this cancer |
| nasopharyngeal carcinoma | linked with Epstein-Barr virus, in Chinese people; non-keratinizing squamous cell carcinoma (undifferentiated) is most common type and very radiosensitive |
| carcinoma of the larynx | cancer seen in men, smokers, usually squamous cell carcinomas; persistent hoarseness |