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Ipratropium Bromide
| Question | Answer |
|---|---|
| GENERIC NAME | IPRATROPIUM BROMIDE |
| BRAND NAME | Atrovent |
| CLASS | anticholinergic, bronchodilator |
| MECHANISM OF ACTION | Anticholinergic (parasympatholytic) agent appears to inhibit vagally-mediated reflexes by antagonizing the action of acetylcholine, the transmitter released from the vagal nerve. |
| INDICATIONS | Treatment of bronchospasm associated with chronic obstructive pulmonary disease (emphysema and chronic bronchitis). To be used either alone or in combination with other bronchodilators especially beta adrenergics (i.e., albuterol). |
| CONTRAINDICATIONS | Ipratropium bromide is contraindicated in known or suspected cases of hypersensitivity to ipratropium bromide or to atropine and its derivatives. Precaution |
| ADVERSE REACTIONS | Coughing, Increased Sputum, Dizziness, Insomnia, Tremor, Nervousness,Nausea |
| NOTES ON ADMINISTRATION | None |
| INCOMPATABILITIES/DRUG INTERACTIONS | None. Ipratropium bromide has been shown to be safe and effective bronchodilator when used in conjunction with beta adrenergic bronchodilators (albuterol) |
| DOSE/ROUTE | Give 500 mcg in 2.5 ml normal saline (1 unit dose vial) via SVN with a mouth piece or in-line with a ventilatory device. Repeat according to medical control preference. May mix one unit dose vial of ipratropium with one unit dose vial of albuterol. |
| ONSET OF ACTION | 5-15 minutes |
| PEAK EFFECTS | 60-120 minutes |
| DURATION OF ACTION | 240-480 minutes |
| AZ DRUG BOX SUPPLY RANGE | 5ml |